AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response.

AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response. Abstract Text:

The analysis of gene expression in Arabidopsis (Arabidopsis thaliana) using cDNA microarrays and reverse transcription-polymerase chain reaction showed that AtOSA1 (A. thaliana oxidative stress-related Abc1-like protein) transcript levels are influenced by Cd(2+) treatment. The comparison of protein sequences revealed that AtOSA1 belongs to the family of Abc1 proteins. Up to now, Abc1-like proteins have been identified in prokaryotes and in the mitochondria of eukaryotes. AtOSA1 is the first member of this family to be localized in the chloroplasts. However, despite sharing homology to the mitochondrial ABC1 of Saccharomyces cerevisiae, AtOSA1 was not able to complement yeast strains deleted in the endogenous ABC1 gene, thereby suggesting different function between AtOSA1 and the yeast ABC1. The atosa1-1 and atosa1-2 T-DNA insertion mutants were more affected than wild-type plants by Cd(2+) and revealed an increased sensitivity toward oxidative stress (hydrogen peroxide) and high light. The mutants exhibited higher superoxide dismutase activities and differences in the expression of genes involved in the antioxidant pathway. In addition to the conserved Abc1 region in the AtOSA1 protein sequence, putative kinase domains were found. Protein kinase assays in gelo using myelin basic protein as a kinase substrate revealed that chloroplast envelope membrane fractions from the AtOSA1 mutant lacked a 70-kD phosphorylated protein compared to the wild type. Our data suggest that the chloroplast AtOSA1 protein is a new factor playing a role in the balance of oxidative stress.

AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Plant physiology

VOLUME: 147

Page Numbers: 719-31

Journal Abbreviation: Plant Physiol.

ISSN: 0032-0889

DAY: 4

MONTH: 04

YEAR: 2008

AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 401224

AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response.

AFFILIATION: University of Zurich, Institute of Plant Biology, 8008 Zurich, Switzerland.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Plant Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response Related Publications

• AtOSA1, a Member of the Abc1-Like Family, as a New Factor in Cadmium and Oxidative Stress Response.
• Carotid plaque screening as a motivational tool for healthy behavior.
• Daniel Bovet - 23 March 1907-8 April 1992.
• Diabetes and pre-diabetes are associated with cardiovascular risk factors and carotid/femoral intima-media thickness independently of markers of insulin resistance and adiposity.
• EFFECTS OF D,1-3-PHTHALIMIDOGLUTARIMIDE AND N-PHTHALYL-D,L-ASPARTIMIDE ON RAT PREGNANCY.
• Metabolic syndrome according to different definitions in a rapidly developing country of the African region.
• Not Available
• Overweight in Swiss Children and Associations With Children's and Parents' Characteristics.
• Prevalence of hypertension in school children.
• Prevalence of hypertension in schoolchildren based on repeated measurements and association with overweight.
• Secular trends in height and weight among children and adolescents of the Seychelles, 1956-2006.
• [A new group of drugs with central paralyzing action.]
• [Blood pressure measurement and screening of hypertension in children]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Pharmacodynamic aspects of ganglion blocking agents with tertiary ammonium function (antihistaminics, spasmolytics and phenothiazine derivatives) recently introduced as anesthetic adjuvants in clinical use.]
• [Results of 219 operations for intraspinal tumors.]
• [Studies on synthetic sympatholytics of ergotamine series; N-substituted derivatives of dl-tetrahydro-beta-naphthylamine with amide and amine functions.]
• [The effect of phenothiazine derivatives and especially of diparcol, parsidol and phenergan on experimentally induced gastric ulcers in rats.]