Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment.

Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment. Research Abstract Details 

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Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment. Abstract Text:

Aashiish Agnihotri,James T Garrett,James Runt,Christopher A Siedlecki,

Polyurethane biomaterials are a critically important class of polymers used in a variety of medical devices. It has been suggested that the good blood compatibility of polyurethanes arises from nanoscale chemical heterogeneities at the surface as a consequence of the microphase separated morphology. In this study, we used tapping mode atomic force microscopy with phase imaging under aqueous conditions to visualize the distribution of the surface microphases for a series of poly(urethane urea) block co-polymers with varying hard segment content. The surfaces were prehydrated for 24 h under a flow of 1 mM phosphate buffer. Topographic images showed the formation of nanometer-sized raised features on the surface, having lateral dimensions of 50-70 nm and heights of 10-15 nm. Phase images, reflecting the local distribution of the mechanical properties under aqueous conditions, were quite different from those obtained in ambient conditions, consistent with water-induced structural reorientation. Images suggest that there is little soft phase material at the polymer surface in the presence of water, while images acquired after dehydration of the samples show that the surface layer remains rich in hard domains, indicating that the films do not return to their original states over the time period studied.

Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment. Publishing Authors By Initials

A Agnihotri,JT Garrett,J Runt,CA Siedlecki,

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Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 17

Page Numbers: 227-38

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2006

Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment. Information

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LANGUAGE: eng

NlmUniqueID: 9007393

Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment. Keywords Mesh Terms:

KEYWORDS: Solutions

MESH TERMS: chemistry

Chemical & Substance for Abstract: Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment. Information

Substance Name: Mitrathane

Registry Number: 97343-15-2

Grant and Affiliation Information for Atomic force microscopy visualization of poly(urethane urea) microphase rearrangements under aqueous environment.

AFFILIATION: Department of Bioengineering, The Pennsylvania State University, College of Medicine, Biomedical Engineering Institute, Hershey 17033, USA.

Country: Netherlands

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MEDLINETA: J Biomater Sci Polym Ed

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