ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Research Abstract Details 

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ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Abstract Text:

Elsa ,Mila Jankovic,Simone Difilippantonio,Jeremy A Daniel,Hua-Tang Chen,Arkady Celeste,Manuela Pellegrini,Kevin McBride,Danny Wangsa,Andrea L Bredemeyer,Barry P Sleckman,Thomas Ried,Michel Nussenzweig, Nussenzweig,

DNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia mutated (ATM) kinase, which suppresses illegitimate joining of DSBs and activates cell-cycle checkpoints. Here we show that a significant fraction of mature ATM-deficient lymphocytes contain telomere-deleted ends produced by failed end joining during V(D)J recombination. These RAG-1/2 endonuclease-dependent, terminally deleted chromosomes persist in peripheral lymphocytes for at least 2 weeks in vivo and are stable over several generations in vitro. Restoration of ATM kinase activity in mature lymphocytes that have transiently lost ATM function leads to loss of cells with terminally deleted chromosomes. Thus, maintenance of genomic stability in lymphocytes requires faithful end joining as well a checkpoint that prevents the long-term persistence and transmission of DSBs. Silencing this checkpoint permits DNA ends produced by V(D)J recombination in a lymphoid precursor to serve as substrates for translocations with chromosomes subsequently damaged by other means in mature cells.

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Publishing Authors By Initials

E ,M Jankovic,S Difilippantonio,JA Daniel,HT Chen,A Celeste,M Pellegrini,K McBride,D Wangsa,AL Bredemeyer,BP Sleckman,T Ried,M Nussenzweig,A Nussenzweig,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

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ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell

VOLUME: 130

Page Numbers: 63-75

Journal Abbreviation: Cell

ISSN: 0092-8674

DAY: 28

MONTH: 06

YEAR: 2007

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Information

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LANGUAGE: eng

NlmUniqueID: 413066

ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Information

Substance Name: Protein-Serine-Threonine Kinases

Registry Number: EC 2.7.11.1

Grant and Affiliation Information for ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

AFFILIATION: Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-1360, USA.

Country: United States

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MEDLINETA: Cell

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