ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks.

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Research Abstract Details 

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ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Abstract Text:

M F Lavin,M F Lavin,M F Lavin,

The recognition and repair of DNA double-strand breaks (DSBs) is a complex process that draws upon a multitude of proteins. This is not surprising since this is a lethal lesion if left unrepaired and also contributes to genome instability and the consequential risk of cancer and other pathologies. Some of the key proteins that recognize these breaks in DNA are mutated in distinct genetic disorders that predispose to agent sensitivity, genome instability, cancer predisposition and/or neurodegeneration. These include members of the Mre11 complex (Mre11/Rad50/Nbs1) and ataxia-telangiectasia (A-T) mutated (ATM), mutated in the human genetic disorder A-T. The mre11 (MRN) complex appears to be the major sensor of the breaks and subsequently recruits ATM where it is activated to phosphorylate in turn members of that complex and a variety of other proteins involved in cell-cycle control and DNA repair. The MRN complex is also upstream of ATM and ATR (A-T-mutated and rad3-related) protein in responding to agents that block DNA replication. To date, more than 30 ATM-dependent substrates have been identified in multiple pathways that maintain genome stability and reduce the risk of disease. We focus here on the relationship between ATM and the MRN complex in recognizing and responding to DNA DSBs.Oncogene (2007) 26, 7749-7758; doi:10.1038/sj.onc.1210880.

ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Publishing Authors By Initials

MF Lavin,MF Lavin,MF Lavin,

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ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncogene

VOLUME: 26

Page Numbers: 7749-58

Journal Abbreviation: Oncogene

ISSN: 1476-5594

DAY: 10

MONTH: Dec

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks.

AFFILIATION: [1] 1Radiation Biology and Oncology Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland, Australia [2] 2Faculty of Health Sciences, University of Queensland, Brisbane, Queensland, Australia.

Country: England

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MEDLINETA: Oncogene

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