Atbf1 is required for the Pit1 gene early activation.

Atbf1 is required for the Pit1 gene early activation. Research Abstract Details 

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Atbf1 is required for the Pit1 gene early activation. Abstract Text:

Yingchuan Qi,Jeffrey A Ranish,Xiaoyan Zhu,Anna Krones,Jie Zhang,Ruedi Aebersold,David W Rose,Michael G Rosenfeld,Catherine Carrière,

Enhancers have been functionally described for >35 years, but the molecular principles underlying the integration of regulatory inputs to alternate gene enhancers used during mammalian organogenesis remain incompletely understood. Using a combination of in vivo enhancer mapping and proteomics approaches, we have established that two distant and distinct early enhancers, each requiring different transcription complexes, are required for full activation of the gene encoding the pituitary lineage determining factor, Pit1. A transcription factor belonging to the "giant, multiple-homeodomain and zinc finger family," Atbf1, serves as a novel pituitary regulator for one of the two required enhancers as shown by genetic and in vitro analysis.

Atbf1 is required for the Pit1 gene early activation. Publishing Authors By Initials

Y Qi,JA Ranish,X Zhu,A Krones,J Zhang,R Aebersold,DW Rose,MG Rosenfeld,C Carrière,

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Atbf1 is required for the Pit1 gene early activation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 105

Page Numbers: 2481-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 1091-6490

DAY: 13

MONTH: 02

YEAR: 2008

Atbf1 is required for the Pit1 gene early activation. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

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Grant and Affiliation Information for Atbf1 is required for the Pit1 gene early activation.

AFFILIATION: Howard Hughes Medical Institute and Department of Medicine, School of Medicine, University of California at San Diego, La Jolla, CA 92093.

Country: United States

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MEDLINETA: Proc Natl Acad Sci U S A

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