Asymmetrical ventricular enlargement in Parkinson's disease.

Asymmetrical ventricular enlargement in Parkinson's disease. Research Abstract Details 

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Asymmetrical ventricular enlargement in Parkinson's disease. Abstract Text:

Xuemei Huang,Yueh Z Lee,Martin McKeown,Guido Gerig,Hongbin Gu,Weili Lin,Mechelle M Lewis,Sutapa Ford,Alexander I ,Daniel R Weinberger,Martin Styner,

Parkinson's disease (PD) typically manifests with asymmetric motor symptom onset. Ventricular enlargement, a nonspecific measure of brain atrophy, has been associated with cognitive decline in PD, but not with motor symptom asymmetry. Asymmetrical ventricular enlargement on magnetic resonance images was explored in a monozygotic twin pair discordant for PD and in nine healthy monozygotic twin pairs. The left-right lateral ventricular volumetric difference of the PD-twin was greater than that of his twin and all other healthy twins, with the larger ventricle observed contralateral to the more symptomatic side. Moreover, the lateral ventricle asymmetry difference between twin pairs was significantly higher for the discordant PD-twin pair than for the healthy twin pairs. This is the first report to suggest the presence of asymmetrical ventricular enlargement in PD, findings that may be worthy of further study.

Asymmetrical ventricular enlargement in Parkinson's disease. Publishing Authors By Initials

X Huang,YZ Lee,M McKeown,G Gerig,H Gu,W Lin,MM Lewis,S Ford,AI ,DR Weinberger,M Styner,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: twin studies as topic research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: twin studies as topic research

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Asymmetrical ventricular enlargement in Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Movement disorders : official journal of the Movem

VOLUME: 22

Page Numbers: 1657-60

Journal Abbreviation: Mov. Disord.

ISSN: 0885-3185

DAY: 15

MONTH: Aug

YEAR: 2007

Asymmetrical ventricular enlargement in Parkinson's disease. Information

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LANGUAGE: eng

NlmUniqueID: 8610688

Asymmetrical ventricular enlargement in Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: Twin Studies as Topic

MESH TERMS: pathology

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Grant and Affiliation Information for Asymmetrical ventricular enlargement in Parkinson's disease.

AFFILIATION: Department of Neurology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599-7025, USA, and University Hospital, Vancouver, British Columbia, Canada. xuemei@med.unc.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR00046

ACRONYM: RR

MEDLINETA: Mov Disord

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