Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision.

Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision. Research Abstract Details 

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Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision. Abstract Text:

Haruaki Ishiyama,Masashi Tsuda,Tadashi Endo,Jun'ichi Kobayashi,Haruaki Ishiyama,Masashi Tsuda,Tadashi Endo,Jun'ichi Kobayashi,

Asymmetric synthesis of double bond isomers (+)-2 (delta(15',16')) and (+)-3 (delta(14',15')) of the structure (1) (delta(16',17')) proposed for pyrinodemin A, a cytotoxic bis-pyridine alkaloid with a unique cis-cyclopent[c]isoxazolidine moiety from a marine sponge, has been accomplished. Pyrinodemin A was indicated to be a 1:1 racemic mixture of 2 from comparison of C(18 )and chiral HPLC analysis for pyrinodemin A and the synthetic compounds as well as ESIMS data of oxidative degradation products of pyrinodemin A.

Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision. Publishing Authors By Initials

H Ishiyama,M Tsuda,T Endo,J Kobayashi,H Ishiyama,M Tsuda,T Endo,J Kobayashi,

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Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecules (Basel, Switzerland)

VOLUME: 10

Page Numbers: 312-6

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ISSN: 1420-3049

DAY: 31

MONTH: 01

YEAR: 2005

Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Asymmetric synthesis of double bond isomers of the structure proposed for pyrinodemin A and indication of its structural revision.

AFFILIATION: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

Country: Switzerland

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MEDLINETA: Molecules

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