Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands.

Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands. Research Abstract Details 

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Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands. Abstract Text:

Carl A Busacca,Jon C Lorenz,Nelu Grinberg,Nizar Haddad,Heewon Lee,Zhibin Li,Mary Liang,Diana Reeves,Anjan Saha,Rich Varsolona,Chris H Senanayake,Carl A Busacca,Jon C Lorenz,Nelu Grinberg,Nizar Haddad,Heewon Lee,Zhibin Li,Mary Liang,Diana Reeves,Anjan Saha,Rich Varsolona,Chris H Senanayake,Carl A Busacca,Jon C Lorenz,Nelu Grinberg,Nizar Haddad,Heewon Lee,Zhibin Li,Mary Liang,Diana Reeves,Anjan Saha,Rich Varsolona,Chris H Senanayake,

Asymmetric hydrogenation of unsaturated urea esters with the BIPI Ligands has been examined. Optimization of the P-N ligand structure has led to the development of chiral rhodium catalysts capable of producing the targets with >99% ee. The critical phosphine borane SNAr reaction needed for ligand synthesis has been optimized to give the adducts in high yield at ambient temperature with no racemization. An extremely concise, economical, and scalable sequence to these important new ligands for catalysis of asymmetric hydrogenation has been developed.

Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands. Publishing Authors By Initials

CA Busacca,JC Lorenz,N Grinberg,N Haddad,H Lee,Z Li,M Liang,D Reeves,A Saha,R Varsolona,CH Senanayake,CA Busacca,JC Lorenz,N Grinberg,N Haddad,H Lee,Z Li,M Liang,D Reeves,A Saha,R Varsolona,CH Senanayake,CA Busacca,JC Lorenz,N Grinberg,N Haddad,H Lee,Z Li,M Liang,D Reeves,A Saha,R Varsolona,CH Senanayake,

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Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic letters

VOLUME: 10

Page Numbers: 341-4

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 21

MONTH: 12

YEAR: 2007

Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands. Information

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LANGUAGE: eng

NlmUniqueID: 100890393

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Grant and Affiliation Information for Asymmetric Hydrogenation of Unsaturated Ureas with the BIPI Ligands.

AFFILIATION: Department of Chemical Development, Boehringer-Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, Ridgefield, Connecticut 06877.

Country: United States

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MEDLINETA: Org Lett

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