Asymmetric focal adhesion disassembly in motile cells.

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Asymmetric focal adhesion disassembly in motile cells. Abstract Text:

Joshua A Broussard,Donna J Webb,Irina Kaverina,Joshua A Broussard,Donna J Webb,Irina Kaverina,

Cell migration requires the integration and coordination of specific focal adhesion dynamics at the cell front, center and rear. In this review, we will present our understanding of the regulation of adhesion turnover and disassembly in various regions of the cell. Adhesion turnover involves a number of tyrosine kinases and phosphatases, most of which are engaged in FAK signaling pathways. Additionally, adhesions are regulated by tensile forces that depend on dynamic coupling with the actin cytoskeleton. The distribution of adhesion disassembly throughout a motile cell is likely coordinated by the asymmetry of the microtubule network. We present a model that suggests two stages of microtubule-driven adhesion disassembly: destabilization and detachment.

Asymmetric focal adhesion disassembly in motile cells. Publishing Authors By Initials

JA Broussard,DJ Webb,I Kaverina,JA Broussard,DJ Webb,I Kaverina,

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Asymmetric focal adhesion disassembly in motile cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in cell biology

VOLUME: 20

Page Numbers: 85-90

Journal Abbreviation: Curr. Opin. Cell Biol.

ISSN: 0955-0674

DAY: 12

MONTH: Feb

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 8913428

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Grant and Affiliation Information for Asymmetric focal adhesion disassembly in motile cells.

AFFILIATION: Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232-8240, USA.

Country: United States

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MEDLINETA: Curr Opin Cell Biol

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