Asymmetric binding of transferrin receptor to parvovirus capsids.

Asymmetric binding of transferrin receptor to parvovirus capsids. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Asymmetric binding of transferrin receptor to parvovirus capsids. Abstract Text:

Susan Hafenstein,Laura M Palermo,Victor A Kostyuchenko,Chuan Xiao,Marc C Morais,Christian D S Nelson,Valorie D Bowman,Anthony J Battisti,Paul R Chipman,Colin R Parrish,Michael G Rossmann,

Although many viruses are icosahedral when they initially bind to one or more receptor molecules on the cell surface, such an interaction is asymmetric, probably causing a breakdown in the symmetry and conformation of the original infecting virion in preparation for membrane penetration and release of the viral genome. Cryoelectron microscopy and biochemical analyses show that transferrin receptor, the cellular receptor for canine parvovirus, can bind to only one or a few of the 60 icosahedrally equivalent sites on the virion, indicating that either canine parvovirus has inherent asymmetry or binding of receptor induces asymmetry. The asymmetry of receptor binding to canine parvovirus is reminiscent of the special portal in tailed bacteriophages and some large, icosahedral viruses. Asymmetric interactions of icosahedral viruses with their hosts might be a more common phenomenon than previously thought and may have been obscured by averaging in previous crystallographic and electron microscopic structure determinations.

Asymmetric binding of transferrin receptor to parvovirus capsids. Publishing Authors By Initials

S Hafenstein,LM Palermo,VA Kostyuchenko,C Xiao,MC Morais,CD Nelson,VD Bowman,AJ Battisti,PR Chipman,CR Parrish,MG Rossmann,

For similar viruses: virion research abstracts see: viruses: virion research

PUBMED ID PMID:

MEDLINE DATE:

Asymmetric binding of transferrin receptor to parvovirus capsids. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 6585-9

Journal Abbreviation:

ISSN: 0027-8424

DAY: 9

MONTH: 04

YEAR: 2007

Asymmetric binding of transferrin receptor to parvovirus capsids. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Asymmetric binding of transferrin receptor to parvovirus capsids. Keywords Mesh Terms:

KEYWORDS: Virion

MESH TERMS: metabolism

Chemical & Substance for Abstract: Asymmetric binding of transferrin receptor to parvovirus capsids. Information

Substance Name: Receptors, Transferrin

Registry Number: 0

Grant and Affiliation Information for Asymmetric binding of transferrin receptor to parvovirus capsids.

AFFILIATION: Department of Biological Sciences, Purdue University, 915 West State Street, West Lafayette, IN 47907-2054, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 33468

ACRONYM: AI

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Asymmetric binding of transferrin receptor to parvovirus capsids Related Publications

• Assembly and crystallization of a T = 1 Icosahedral particle from trypsinized southern bean mosaic virus coat protein.
• Asymmetric binding of transferrin receptor to parvovirus capsids.
• Binding of a neutralizing antibody to dengue virus alters the arrangement of surface glycoproteins.
• Carbon-13 NMR study of southern bean mosaic virus.
• Cryo-electron microscopy study of bacteriophage T4 displaying anthrax toxin proteins.
• Crystal and cryoEM structural studies of a cell wall degrading enzyme in the bacteriophage phi29 tail.
• Defining Molecular and Domain Boundaries in the Bacteriophage varphi29 DNA Packaging Motor.
• Determinants of bacteriophage phi29 head morphology.
• Insight into DNA and protein transport in double-stranded DNA viruses: the structure of bacteriophage n4.
• Minute virus of mice, a parvovirus, in complex with the Fab fragment of a neutralizing monoclonal antibody.
• Structural analysis of viral nucleocapsids by subtraction of partial projections.
• Structural changes of bacteriophage phi29 upon DNA packaging and release.
• Structure and function of a chlorella virus-encoded glycosyltransferase.
• Structure of immature West Nile virus.
• Structure of the Bacteriophage {varphi}KZ Lytic Transglycosylase gp144.
• The coiled-coil domain structure of the Sin Nombre virus nucleocapsid protein.
• The flavivirus precursor membrane-envelope protein complex: structure and maturation.
• The location of calcium ions in southern bean mosaic virus.
• Visualization of the externalized VP2 N termini of infectious human parvovirus B19.
• [Convergence irradiation of bladder tumors.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Tangential oscillating radiotherapy of breast cancer.]