Asthma: non-responsiveness to conventional therapy.

Asthma: non-responsiveness to conventional therapy. Research Abstract Details 

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Asthma: non-responsiveness to conventional therapy. Abstract Text:

A S Rebuck,

Despite regular inhalation of beta-agonists, topical steroids and anticholinergic aerosols and the achievement of therapeutic blood levels of theophylline, some asthmatics have rapidly fluctuating levels of peak flow measurements throughout the day. Often little or no improvement is obtained with larger doses of corticosteroids. Before embarking on more intense drug therapy, attention should be paid to conscientious adherence to the prescribed regimen and avoidance of aspirin and tartrazine, as well as to exposure to allergens such as those associated with household pets. A number of newer therapeutic options are related to the use of air jet or ultrasonic nebulizers, that allow liquid forms of inhalation agents to be taken slowly in the home environment. In this regard, combination therapy with a beta-agonist and the anticholinergic ipratropium has been shown to have bronchodilating properties superior to either agent used alone. Secondly, sodium cromoglycate in its liquid form appears to have bronchodilator properties; taken on a regular basis, four times per day, it appears to have a steroid-sparing effect. Two alternatives are available for increasing the intensity of corticosteroid therapy, other than by prolonged, high-dose prednisone. The first is that of high-dose inhaled beclomethasone (up to 2000 micrograms/day) using the 250 micrograms/puff inhaler. The second is that of intravenous therapy with methylprednisolone, recently shown to have lung permeability superior to that of prednisolone. Office patients can be treated with occasional or even regular 'pulse' doses of methylprednisolone, an approach that is now finding acceptance in the management of the inflammatory alveolitides.

Asthma: non-responsiveness to conventional therapy. Publishing Authors By Initials

AS Rebuck,

For similar behavior and behavior mechanisms: behavior: health behavior: patient compliance research abstracts see: behavior and behavior mechanisms: behavior: health behavior: patient compliance research

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Asthma: non-responsiveness to conventional therapy. Journal Published:

PUBLICATION TYPE: Review

Journal: European journal of respiratory diseases. Suppleme

VOLUME: 147

Page Numbers: 105-9

Journal Abbreviation:

ISSN: 0106-4347

DAY: 21

MONTH: 02

YEAR: 1986

Asthma: non-responsiveness to conventional therapy. Information

Number of References: 11

LANGUAGE: eng

NlmUniqueID: 8010618

Asthma: non-responsiveness to conventional therapy. Keywords Mesh Terms:

KEYWORDS: Patient Compliance

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Asthma: non-responsiveness to conventional therapy. Information

Substance Name: Methylprednisolone

Registry Number: 83-43-2

Grant and Affiliation Information for Asthma: non-responsiveness to conventional therapy.

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Country: DENMARK

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MEDLINETA: Eur J Respir Dis Suppl

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