Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women.

Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Research Abstract Details 

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Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Abstract Text:

Giske Ursin,Can-Lan Sun,Woon-Puay Koh,Kei-Siong Khoo,Fei Gao,Anna H Wu,Mimi C Yu,

Although the evidence is not completely consistent, soy intake has been inversely associated with breast cancer risk, and the strongest results have been observed in certain Asian populations. To address this issue and to examine the association between mammographic density and reproductive factors in this population, we conducted a cross-sectional analysis of mammograms and validated food-frequency questionnaires from 380 Chinese women living in Singapore. Percent mammographic density, a biomarker for breast cancer risk, was assessed using a validated computer-assisted method. We used generalized linear models to estimate mean mammographic density by quartiles of soy intake and intake of other dietary factors while adjusting for potential confounders. Percent mammographic density was inversely associated with age, body mass index, parity, breastfeeding, and soy intake. The difference in mammographic density between the highest and lowest quartiles of soy intake was 4-5%; this difference was statistically significant for soy protein and soy isoflavone intake and is similar in magnitude to what has been reported in Western populations when women undergo menopause or commence hormone therapy. We found no evidence that high fiber, fruit, or vegetable intake has protective effects on mammographic density. Our results suggest that the effect of soy intake on percent mammographic density is moderate but possibly of clinical relevance.

Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Publishing Authors By Initials

G Ursin,CL Sun,WP Koh,KS Khoo,F Gao,AH Wu,MC Yu,

For similar soy foods research abstracts see: soy foods research

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MEDLINE DATE:

Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Nutrition and cancer

VOLUME: 56

Page Numbers: 128-35

Journal Abbreviation:

ISSN: 0163-5581

DAY: 3

MONTH: 12

YEAR: 2006

Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7905040

Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Keywords Mesh Terms:

KEYWORDS: Soy Foods

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women. Information

Substance Name: Isoflavones

Registry Number: 0

Grant and Affiliation Information for Associations between soy, diet, reproductive factors, and mammographic density in Singapore Chinese women.

AFFILIATION: University of Southern California, Los Angeles, CA 90089, USA. gursin@usc.edu

Country: United States

AGENCY: United States NCI

GRANT: R35CA53890

ACRONYM: CA

MEDLINETA: Nutr Cancer

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