Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.

Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Research Abstract Details 

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Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Abstract Text:

Neelam Dhiman,Inna G Ovsyannikova,Julie M Cunningham,Robert A Vierkant,Richard B Kennedy,V Shane Pankratz,Gregory A Poland,Robert M Jacobson,

BACKGROUND: Cytokines are key regulators of measles vaccine humoral and cellular immunity. Single-nucleotide polymorphisms (SNPs) that are associated with differences in cytokine levels should also influence measles vaccine-induced immunity. METHODS: We genotyped 118 measles-mumps-rubella-vaccinated subjects for SNPs from 6 cytokine genes (interleukin [IL]-2, IL-4, IL-10, IL-12A, IL-12B, and interferon [IFN]-gamma) and their receptors (IL-2RA, IL-2RB, IL-4RA, IL-10RA, IL-10RB, IL-12RB1, IL-12RB2, and IFN-gamma R). Associations of SNPs with measles-specific antibodies, lymphoproliferation, and secreted cytokines were determined using chi2 tests and analyses of covariance. RESULTS: We found significant associations (P<.05) between SNPs in the IL-2, IL-10, and IL-12RB genes and measles vaccine-induced immunity. The IVS1-100G (rs2069762) and the Ex2-34G (rs2069763) SNPs within the IL-2 gene were associated with high antibody and high lymphoproliferative responses, whereas SNPs within the IL-10 and IL-12R genes were associated with low antibody and lymphoproliferative responses to measles. SNPs within the IL-4RA and IL-12B genes varied significantly (P<.05) across immune response measures. Significant associations were also found between SNPs and secreted cytokine levels. CONCLUSIONS: Specific SNPs in the cytokine and cytokine receptor genes are significantly associated with variations in measures of the immune response to measles vaccination. These results need to be further validated in a larger cohort.

Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Publishing Authors By Initials

N Dhiman,IG Ovsyannikova,JM Cunningham,RA Vierkant,RB Kennedy,VS Pankratz,GA Poland,RM Jacobson,

For similar proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, cytokine research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, immunologic: receptors, cytokine research

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Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of infectious diseases

VOLUME: 195

Page Numbers: 21-9

Journal Abbreviation: J. Infect. Dis.

ISSN: 0022-1899

DAY: 20

MONTH: 11

YEAR: 2006

Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413675

Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Keywords Mesh Terms:

KEYWORDS: Receptors, Cytokine

MESH TERMS: physiology

Chemical & Substance for Abstract: Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes. Information

Substance Name: Interferon Type II

Registry Number: 82115-62-6

Grant and Affiliation Information for Associations between measles vaccine immunity and single-nucleotide polymorphisms in cytokine and cytokine receptor genes.

AFFILIATION: Mayo Vaccine Research Group, Mayo Clinic, Rochester, MN 55905, USA.

Country: United States

AGENCY: United States NCRR

GRANT: M01-RR00585

ACRONYM: RR

MEDLINETA: J Infect Dis

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