Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts.

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Abstract Text:

Serotonin (5-HT) receptors may have a role in suicidal behavior. Previous studies have shown an association between the T102C polymorphism of the 5-HT2a receptor gene and suicidal behavior. However, negative findings have also been reported. We examined the association between the T102C and C1354T (His452Tyr) polymorphisms of the 5-HT2a receptor gene and suicide attempts. Four hundred forty-one suicide attempters, 339 psychiatric patients, and 410 healthy controls were compared for genotypes of the T102C and C1354T (His452Tyr) polymorphisms. There were significant differences in the distribution of the three genotypes (TT, TC, and CC) of the T102C polymorphism in the three groups (controls, psychiatric patients, and suicide attempters). There was an excess of C/C genotypes in the suicide attempter group compared with the control group, but there were no significant differences between suicide attempters and psychiatric controls. We found no association between the C1354T polymorphism and suicide attempts. The C allele of the T102C polymorphism of the 5-HT2A receptor gene may be associated with biological susceptibility for suicidal behavior or psychiatric conditions. (c) 2007 Wiley-Liss, Inc.

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 147B

Page Numbers: 645-9

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-485X

DAY: 5

MONTH: Jul

YEAR: 2008

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101235742

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts.

AFFILIATION: Department of Biology, Autonoma University of Madrid, Madrid, Spain.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Am J Med Genet B Neuropsychiat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts Related Publications

• Association study of two polymorphisms of the serotonin-2A receptor gene and suicide attempts.
• Bipolar disorders in children and adolescents: dilemmas in their pathophysiology, diagnosis and treatment.
• Cluster C personality disorders in major depressive episodes: the relationship between hostility and suicidal behavior.
• Comorbid anxiety in bipolar disorder: does it have an independent effect on suicidality?
• Completed suicide in childhood.
• Depressed patients with co-occurring alcohol use disorders: a unique patient population.
• Does first episode polarity predict risk for suicide attempt in bipolar disorder?
• Family history of suicidal behavior and early traumatic experiences: Additive effect on suicidality and course of bipolar illness?
• Neurobiology of suicidal behavior. An integration of biological and clinical findings.
• No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover.
• Protective factors against suicidal behavior in depressed adults reporting childhood abuse.
• Serotonergic responses in depressed patients with or without a history of alcohol use disorders and healthy controls.
• Suicidal behavior in young women.
• The role of moral objections to suicide in the assessment of suicidal patients.
• Triggers for suicidal behavior in depressed older adolescents and young adults: do alcohol use disorders make a difference?