Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder.

Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Research Abstract Details 

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Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Abstract Text:

J Lee,N Laurin,J Crosbie,A Ickowicz,T Pathare,M Malone,J L Kennedy,R Tannock,R Schachar,C L Barr,J Lee,N Laurin,J Crosbie,A Ickowicz,T Pathare,M Malone,J L Kennedy,R Tannock,R Schachar,C L Barr,

Attention-deficit hyperactivity disorder (ADHD) is a common childhood-onset psychiatric condition with a strong genetic component. Evidence from pharmacological, clinical and animal studies has suggested that the nicotinic system could be involved in the disorder. Previous studies have implicated the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in ADHD. Particularly, a polymorphism in the exon 2-intron 2 junction of CHRNA4 has been associated with severe inattention defined by latent class analysis. In the current study, we used the transmission disequilibrium test (TDT) to investigate four polymorphisms encompassing this region of CHRNA4 for association with ADHD in a sample of 264 nuclear families from Toronto. No significant evidence of biased transmission was observed for any of the marker alleles for ADHD defined as a categorical trait (all subtypes included), although one haplotype showed marginal evidence of under-transmission. No association was found with the ADHD predominantly inattentive subtype or with symptom dimension scores of inattention. On the contrary, nominally significant evidence of association of individual markers was obtained for the ADHD combined subtype and with teacher-rated hyperactivity-impulsivity scores, with the same haplotype being under-transmitted. Based on our results and others, CHRNA4 may be involved in ADHD; however, its role in ADHD symptomatology remains to be clarified.

Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Publishing Authors By Initials

J Lee,N Laurin,J Crosbie,A Ickowicz,T Pathare,M Malone,JL Kennedy,R Tannock,R Schachar,CL Barr,J Lee,N Laurin,J Crosbie,A Ickowicz,T Pathare,M Malone,JL Kennedy,R Tannock,R Schachar,CL Barr,

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Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genes, brain, and behavior

VOLUME: 7

Page Numbers: 53-60

Journal Abbreviation: Genes Brain Behav.

ISSN: 1601-1848

DAY: 14

MONTH: 05

YEAR: 2007

Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder. Information

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LANGUAGE: eng

NlmUniqueID: 101129617

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Grant and Affiliation Information for Association study of the nicotinic acetylcholine receptor alpha4 subunit gene, CHRNA4, in attention-deficit hyperactivity disorder.

AFFILIATION: Division of Genetics and Development, Toronto Western Research Institute, University Health Network, Toronto, ON, Canada.

Country: England

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MEDLINETA: Genes Brain Behav

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