Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3.

Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Research Abstract Details 

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Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Abstract Text:

K Kyo,M Parkes,Y Takei,H Nishimori,P Vyas,J Satsangi,J Simmons,H Nagawa,S Baba,D Jewell,T Muto,G M Lathrop,Y Nakamura,

Ulcerative colitis (UC), a common form of inflammatory bowel disease, is a multifactorial disorder with significant genetic influence. Recently, evidence of linkage on chromosome 7q near the intestinal mucin gene MUC3 was reported by an affected sib-pair analysis. Previous reports indicate a possible mucin abnormality in UC patients, but whether genetic differences in a specific mucin gene are associated with UC is unknown. Here we analysed polymorphisms of variable number of tandem repeats (VNTRs) within this gene using DNAs obtained from 243 Japanese (75 patients with UC and 168 controls), and to confirm the result we undertook a two-stage examination using 328 Caucasian samples (72 and 85 with UC in the first and second stages, respectively, and 171 controls). When the frequency of patients carrying one or two rare VNTR alleles was compared with that of controls, a significant increase was found first in Japanese patients (odds ratio 2.72, 95% CI 1.17-6.32, P = 0. 0308). In Caucasians, the odds ratio was 2.80 (95% CI 1.36-5.75, P = 0.0079) in the first stage, 2.43 (95% CI 1.20-4.92, P = 0.0196) in the second stage and 2.60 (95% CI 1.41-4.80, P = 0.0024) in total. The overall odds ratio was 2.64 (95% CI 1.60-4.33, P = 0.0001). This result suggests that rare alleles of the MUC3 gene may confer genetic predisposition to UC.

Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Publishing Authors By Initials

K Kyo,M Parkes,Y Takei,H Nishimori,P Vyas,J Satsangi,J Simmons,H Nagawa,S Baba,D Jewell,T Muto,GM Lathrop,Y Nakamura,

For similar genetic phenomena: variation (genetics): polymorphism, genetic research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic research

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Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Human molecular genetics

VOLUME: 8

Page Numbers: 307-11

Journal Abbreviation: Hum. Mol. Genet.

ISSN: 0964-6906

DAY: 1

MONTH: Feb

YEAR: 1999

Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Information

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LANGUAGE: eng

NlmUniqueID: 9208958

Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Association of ulcerative colitis with rare VNTR alleles of the human intestinal mucin gene, MUC3.

AFFILIATION: Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.

Country: ENGLAND

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MEDLINETA: Hum Mol Genet

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