[Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province]

[Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province] Research Abstract Details 

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[Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province] Abstract Text:

Min Luo,Yuan-li He,Hong-bin Zhang,Dong-xiang Shen,Li-li Zong,Ting Guan,

OBJECTIVE: To study the polymorphism of +252 site in intron 1 of tumor necrosis factor (TNF)-beta gene in relation to genetic susceptibility of endometriosis. METHODS: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed to detect the polymorphism of +252 site in intron 1 of TNF-beta gene in 82 Chinese Han patients with endometriosis in Guangdong Province and 80 Han patients without endometriosis (control group), and the relation between TNF gene polymorphism and the risk of endometriosis was analyzed. RESULTS: The +252 site of TNF-beta allele and genotype distribution showed significant difference between endometriosis and control groups (Chi2=6.562, P<0.05; chi2=6.562, P<0.05), and relative risk of endometriosis in relation to allele A was increased by 1.793 fold. The risk of endometriosis was 3.33-fold higher in women of AA genotype than those of GG genotype (Chi2=6.562, P<0.05). CONCLUSIONS: Allele A in TNF-beta gene +252 site can significantly increase the relative risk of endometriosis in women in Guangdong, among which TNF-beta AA genotype might be one of the genetic susceptible factors for endometriosis.

[Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province] Publishing Authors By Initials

M Luo,YL He,HB Zhang,DX Shen,LL Zong,T Guan,

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[Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nan fang yi ke da xue xue bao = Journal of Souther

VOLUME: 26

Page Numbers: 1163-5

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ISSN: 1673-4254

DAY: 30

MONTH: Aug

YEAR: 2006

[Association of tumor necrosis factors-beta gene polymorphism with endometriosis in women in Guangdong Province] Information

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LANGUAGE: chi

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AFFILIATION: Department of Obstetrics and Gynecology, Guangzhou General Hospital of Guangzhou Command, Guangzhou 510010, China. shendx1970@yahoo.com.cn

Country: China

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MEDLINETA: Nan Fang Yi Ke Da Xue Xue Bao

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