Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus.

Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus. Abstract Text:

BACKGROUND AND DESIGN: We have observed that tissue-fixed deposits of immunoglobulin (Ig) are occasionally present in the cytoplasm (CYT) of epidermal keratinocytes. This study was conducted to examine the frequency, significance, and possible cause of this finding. RESULTS: Direct immunofluorescence studies were performed on 302 sequential skin specimens obtained from patients with lupus erythematosus (n = 98), bullous diseases (n = 114), or other dermatoses (n = 90). Abnormal epidermal CYT deposits were observed in 22 of the patients with lupus erythematosus (22.5%), four of those with bullous diseases (3.5%), and two of those with other dermatoses (2.2%). The deposits were more common in systemic than in discoid lupus erythematosus, and in skin lesions than in normal skin. By indirect immunofluorescence, circulating antibodies to epidermal upper CYT antigens were present in 100% of 12 patients with tissue-fixed CYT deposits (average antibody titer, 300) and in 21% of 19 individuals without CYT deposits (average titer, 43). By Western immunoblot analysis these antibodies were directed to proteins in keratin extracts of skin. CONCLUSIONS: These findings indicate that deposits of Ig in the cytoplasm of keratinocytes in human skin are associated with high levels of serum antibodies to upper CYT antigens and with lupus erythematosus.

Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus. Publishing Authors By Initials

For similar skin and connective tissue diseases: skin diseases: skin diseases, vesiculobullous research abstracts see: skin and connective tissue diseases: skin diseases: skin diseases, vesiculobullous research

PUBMED ID PMID:

MEDLINE DATE:

Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of dermatology

VOLUME: 129

Page Numbers: 1130-5

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Sep

YEAR: 1993

Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372433

Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus. Keywords Mesh Terms:

KEYWORDS: Skin Diseases, Vesiculobullous

MESH TERMS: pathology

Chemical & Substance for Abstract: Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus. Information

Substance Name: Immunoglobulins

Registry Number: 0

Grant and Affiliation Information for Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus.

AFFILIATION: Department of Dermatology, Aristotle University Medical School, Thessaloniki, Greece.

Country: UNITED STATES

AGENCY: United States FIC

GRANT: F05-TWO4200-01

ACRONYM: TW

MEDLINETA: Arch Dermatol

REFSOURCE: Arch Dermatol. 1993 Sep;129(9):1184-7

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus Related Publications

• A novel bullous pemphigoid antigen (BP125) located in the deeper layers of the basement membrane zone.
• Adjuvant therapy of pemphigus.
• An alternate explanation for the increase in the incidence of melanoma being restricted to patients with thin lesions.
• Antibodies to melanocytes. Occurrence in patients with vitiligo and chronic mucocutaneous candidiasis.
• Association of tissue-fixed cytoplasmic deposits of immunoglobulin in epidermal keratinocytes with lupus erythematosus.
• Bullous pemphigoid antibodies. Human skin as a substrate for indirect immunofluorescence assay.
• Clinical activity of a polyvalent melanoma antigen vaccine.
• Clinical significance of basal cell layer antibodies.
• Comparative effectiveness of azathioprine or mycophenolate mofetil as an adjuvant for the treatment of bullous pemphigoid.
• Erythema multiforme with mucous membrane involvement and Stevens-Johnson syndrome are clinically different disorders.
• Expression of toxic epidermal necrolysis in grafted skin is donor-site dominant.
• Hair follicle structures targeted by antibodies in patients with alopecia areata.
• Heterogeneity of pemphigus vulgaris antigens.
• Improvement of intravenous immunoglobulin therapy for bullous pemphigoid by adding immunosuppressive agents: marked improvement in depletion of circulating autoantibodies.
• Ineffectiveness of cyclosporine as an adjuvant to corticosteroids in the treatment of pemphigus.
• Intercellular deposits of complement in skin of patients with pemphigus.
• Intravenous immunoglobulin selectively decreases circulating autoantibodies in pemphigus.
• Kinetics of response to conventional treatment in patients with pemphigus vulgaris.
• Letter: Antiepithelial antibodies: a possible clue to malignant neoplasms.
• Limitations of direct immunofluorescence.
• Melanoma and vitiligo are associated with antibody responses to similar antigens on pigment cells.
• Oral psoralen with UV-A therapy releases circulating growth factor(s) that stimulates cell proliferation.
• Pemphigus foliaceus associated with absence of intercellular antigens in lower layers of epidermis.
• Plasmapheresis and immunosuppressive therapy. Effect on levels of intercellular antibodies in pemphigus vulgaris.
• Plasmapheresis therapy of pemphigus.
• Relation between skin temperature and location of facial lesions in seborrheic dermatitis.
• TLR7 imidazoquinoline ligand 3M-019 is a potent adjuvant for pure protein prototype vaccines.
• Variability of the lupus band test. Results in 18 patients with systemic lupus erythematosus.
• Vitiligo antibodies are not directed to tyrosinase.