Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development.

Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development. Research Abstract Details 

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Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development. Abstract Text:

Nagako Yoshiba,Kunihiko Yoshiba,Akihiro Hosoya,Masahiro Saito,Takamasa Yokoi,Takashi Okiji,Norio Amizuka,Hidehiro Ozawa,Nagako Yoshiba,Kunihiko Yoshiba,Akihiro Hosoya,Masahiro Saito,Takamasa Yokoi,Takashi Okiji,Norio Amizuka,Hidehiro Ozawa,Nagako Yoshiba,Kunihiko Yoshiba,Akihiro Hosoya,Masahiro Saito,Takamasa Yokoi,Takashi Okiji,Norio Amizuka,Hidehiro Ozawa,

Matrix remodeling is regulated by matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). Periostin, originally identified in a mouse osteoblastic library, plays a role in cell adhesion and migration and in mechanical stress-induced matrix remodeling. In this study, we analyzed and compared the distribution patterns of TIMP-2 and periostin during mouse mandible development. Immunohistochemical staining for TIMP-2 and periostin was carried out on serial cryosections obtained from mice at embryonic days 13-16, postnatal day 2 (P2), P35, and 12 weeks of age. TIMP-2 and periostin exhibited a strikingly similar protein distribution during mandible development. From bud to early bell stages of molars, TIMP-2 and periostin were highly expressed on the lingual and anterior sides of the basement membrane and on the adjacent jaw mesenchyme. In pre- and postnatal incisors, the basement membrane of the apical loop and dental follicle was immunostained for TIMP-2 and periostin. At postnatal stages, TIMP-2 and periostin were prominently confined to the extracellular matrix (ECM) of gingival tissues, periodontal ligaments, and tendons (all recipients of mechanical strain). However, periostin was solely detected in the lower portion of the inner root sheath of hair follicles. Gingiva of P2 cultured in anti-TIMP-2 antibody-conditioned medium showed markedly reduced staining of periostin. We suggest that TIMP-2 and periostin are co-distributed on ECM exposed to mechanical forces and coordinately function as ECM modulators.

Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development. Publishing Authors By Initials

N Yoshiba,K Yoshiba,A Hosoya,M Saito,T Yokoi,T Okiji,N Amizuka,H Ozawa,N Yoshiba,K Yoshiba,A Hosoya,M Saito,T Yokoi,T Okiji,N Amizuka,H Ozawa,N Yoshiba,K Yoshiba,A Hosoya,M Saito,T Yokoi,T Okiji,N Amizuka,H Ozawa,

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Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell and tissue research

VOLUME: 330

Page Numbers: 133-45

Journal Abbreviation: Cell Tissue Res.

ISSN: 0302-766X

DAY: 30

MONTH: 06

YEAR: 2007

Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development. Information

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LANGUAGE: eng

NlmUniqueID: 417625

Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development. Keywords Mesh Terms:

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Grant and Affiliation Information for Association of TIMP-2 with extracellular matrix exposed to mechanical stress and its co-distribution with periostin during mouse mandible development.

AFFILIATION: Division of Cariology, Operative Dentistry and Endodontics, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, 5274 Gakkocho-dori 2-bancho, Niigata, 951-8514, Japan, nagako@dent.niigata-u.ac.jp.

Country: Germany

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MEDLINETA: Cell Tissue Res

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