Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population.

Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Research Abstract Details 

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Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Abstract Text:

Kang Shan,Ma Xiao-Wei,Wang Na,Zhang Xiu-Feng,Wen Deng-Gui,Guo Wei,Zhang Zheng-Mao,Li Yan,Kang Shan,Ma Xiao-Wei,Wang Na,Zhang Xiu-Feng,Wen Deng-Gui,Guo Wei,Zhang Zheng-Mao,Li Yan,

Endometriosis, one of the most frequent diseases in gynecology, is a benign but invasive and metastatic disease. The altered expression of E-cadherin may play an important role in developing endometriosis. In this paper, we discuss the association of three single nucleotide polymorphisms (SNPs) on the E-cadherin gene and risk of endometriosis. We examined the genotype frequency of three polymorphisms in 152 endometriosis patients and 189 control women. There was a significant difference in the frequency of the E-cadherin 3'-UTR C --> T genotypes between endometriosis and controls (P = 0.01). The frequency of the C allele in patients (71.1%) was significantly higher than in the controls (63.8%; P = 0.04). When compared with the T/T + T/C genotypes, the C/C genotype had a significantly increased susceptibility to endometriosis, with an adjusted odds ratio of 1.79 (95% confidence interval = 1.17-2.76). No significant difference was found between endometriosis and control women on two polymorphisms (-160 C --> A, -347 G --> GA) at the gene promoter region of E-cadherin. The -160 C --> A and -347 G --> GA polymorphisms displayed linkage disequilibrium (D' = 0.999). The -160 A/-347 GA haplotype was only detected in endometriosis patients (2%). These data show a relation between the E-cadherin 3'-UTR C --> T polymorphism, the -160 A/-347 GA haplotype of two promoter polymorphisms and risk of endometriosis, suggesting a potential role in endometriosis development, at least in North Chinese women.

Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Publishing Authors By Initials

K Shan,M Xiao-Wei,W Na,Z Xiu-Feng,W Deng-Gui,G Wei,Z Zheng-Mao,L Yan,K Shan,M Xiao-Wei,W Na,Z Xiu-Feng,W Deng-Gui,G Wei,Z Zheng-Mao,L Yan,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk research

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Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Reproduction (Cambridge, England)

VOLUME: 134

Page Numbers: 373-8

Journal Abbreviation: Reproduction

ISSN: 1470-1626

DAY: 27

MONTH: Aug

YEAR: 2007

Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Information

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LANGUAGE: eng

NlmUniqueID: 100966036

Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Keywords Mesh Terms:

KEYWORDS: Risk

MESH TERMS: genetics

Chemical & Substance for Abstract: Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population. Information

Substance Name: Cadherins

Registry Number: 0

Grant and Affiliation Information for Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population.

AFFILIATION: Department of Obstetrics and Gynecology, Fourth Hospital, Hebei Medical University, Shijiazhuang 050011, China.

Country: England

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MEDLINETA: Reproduction

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