Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado.

Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. Research Abstract Details 

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Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. Abstract Text:

Tracy L Nelson,Tasha E Fingerlin,Laurie K Moss,M Michael Barmada,Robert E Ferrell,Jill M Norris,

The objective of the study was to test for an association between type 2 diabetes mellitus (T2DM) and the Pro12Ala polymorphism in the peroxisome proliferator-activated receptor gamma gene (PPAR-gamma) in families from Colorado. We were also interested in whether there was any modification by diet or physical activity. We studied 216 Hispanic pedigrees (1850 nuclear families) and 236 non-Hispanic white (NHW) pedigrees (1240 families) from the San Luis Valley and Denver, CO. We genotyped the Pro12Ala polymorphism of the PPAR-gamma gene. Historical physical activity (average metabolic equivalent task units per week) as well as average dietary intake over the past year was assessed by self-report. Using the family-based association test, we found that in NHWs the Pro12 allele was associated with T2DM only among those with low physical activity (P = .006), or with high polyunsaturated fat intake (P = .034). A significant interaction between low physical activity and the Pro12 allele in association with T2DM was also detected using generalized estimating equations models (P = .022). Furthermore, after stratifying by physical activity similar to the family-based association test, we found the Pro12 allele was significantly associated with T2DM in those with low physical activity (odds ratio, 2.37; 95% confidence interval, 1.14-4.94). There may be a gene-environment interaction between the Pro12 allele of the PPAR-gamma gene and physical activity that results in increased risk of T2DM in NHWs.

Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. Publishing Authors By Initials

TL Nelson,TE Fingerlin,LK Moss,MM Barmada,RE Ferrell,JM Norris,

For similar proteins: receptors, cytoplasmic and nuclear: peroxisome proliferator-activated receptors: ppar gamma research abstracts see: proteins: receptors, cytoplasmic and nuclear: peroxisome proliferator-activated receptors: ppar gamma research

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Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Metabolism: clinical and experimental

VOLUME: 56

Page Numbers: 388-93

Journal Abbreviation: Metab. Clin. Exp.

ISSN: 0026-0495

DAY: 3

MONTH: Mar

YEAR: 2007

Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. Information

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LANGUAGE: eng

NlmUniqueID: 375267

Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. Keywords Mesh Terms:

KEYWORDS: PPAR gamma

MESH TERMS: genetics

Chemical & Substance for Abstract: Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado. Information

Substance Name: PPAR gamma

Registry Number: 0

Grant and Affiliation Information for Association of the peroxisome proliferator-activated receptor gamma gene with type 2 diabetes mellitus varies by physical activity among non-Hispanic whites from Colorado.

AFFILIATION: Department of Health and Exercise Science, Colorado State University, Fort Collins, CO 80523, USA. tnelson@cahs.colostate.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R01-DK-49632

ACRONYM: DK

MEDLINETA: Metabolism

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