Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil.

Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. Research Abstract Details 

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Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. Abstract Text:

Brum,Amilton Antunes Barreira,Paulo Louzada-Junior,Celso Teixeira Mendes-Junior, Donadi,

Multiple sclerosis (MS) is a multifactorial inflammatory disease that primarily affects the central nervous system. Genes and environmental factors probably interact in MS susceptibility and outcome; however, their roles have not been elucidated yet. The evaluation of the HLA-DRB1 gene in the Brazilian population is of particular interest in evidencing the behavior of HLA-DRB1 alleles in a highly admixed population inserted in an environment of low MS prevalence. The present results suggest that a given HLA-DRB1 allele may exhibit different behaviors, i.e. confer resistance or susceptibility, in response to the environmental and/or genetic (ethnic) backgrounds that characterize a sampled population.

Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. Publishing Authors By Initials

DG Brum,AA Barreira,P Louzada-Junior,CT Mendes-Junior,EA Donadi,

For similar persons: population groups research abstracts see: persons: population groups research

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Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of neuroimmunology

VOLUME: 189

Page Numbers: 118-24

Journal Abbreviation: J. Neuroimmunol.

ISSN: 0165-5728

DAY: 2

MONTH: 08

YEAR: 2007

Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. Information

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LANGUAGE: eng

NlmUniqueID: 8109498

Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. Keywords Mesh Terms:

KEYWORDS: Population Groups

MESH TERMS: genetics

Chemical & Substance for Abstract: Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil. Information

Substance Name: HLA-DRB1 antigen

Registry Number: 128338-86-3

Grant and Affiliation Information for Association of the HLA-DRB1*15 allele group and the DRB1*1501 and DRB1*1503 alleles with multiple sclerosis in White and Mulatto samples from Brazil.

AFFILIATION: Department of Neurology, Medical School of Ribeirão Preto, University of São Paulo. Av. Bandeirantes, 3900, 14049-900, Ribeirão Preto, SP, Brazil.

Country: Netherlands

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MEDLINETA: J Neuroimmunol

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