Association of testis derived transcript gene variants and prostate cancer risk.

Association of testis derived transcript gene variants and prostate cancer risk. Research Abstract Details 

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Association of testis derived transcript gene variants and prostate cancer risk. Abstract Text:

Xin Liu,Mine S Cicek,Sarah J Plummer,Eric Jorgenson,Graham Casey,John S Witte,

PURPOSE: The testis derived transcript gene has been suggested as a tumor suppressor gene for prostate cancer at 7q31. To investigate this concept we evaluated the effects of 7 tagging single nucleotide polymorphisms that comprehensively captured the common genetic variants in TES on aggressive prostate cancer in a case-control study. MATERIALS AND METHODS: A total of 506 cases diagnosed with aggressive prostate cancer, and an equal number of age, institute and ethnicity matched controls, were recruited from the major medical institutions in Cleveland, Ohio. A logistic regression model was used to evaluate the association between SNPs/multimarker haplotypes and prostate cancer. RESULTS: When looking at all study subjects and white men only, no statistically significant associations were observed between any variants and more aggressive disease. However, 3 variants showed inverse associations with disease in black men (178), including 2 intronic SNPs (rs2402056, rs1004109) and 1 SNP close to the 3' untranslated region (rs4730721) with ORs of 0.57 (95% CI 0.36-0.90, under an additive mode of inheritance), 0.57 (95% CI 0.36-0.91, under an additive mode of inheritance) and 0.45 (95% CI 0.21-0.98, under a dominant mode of inheritance), respectively. Variants rs2402056 and rs1004109 are in tight linkage disequilibrium (r2=0.8) and the reconstructed haplotype did not provide any additional evidence for association than their genotype level results. CONCLUSIONS: Our findings suggest that the variants in TES, or in a nearby gene, may be associated with prostate cancer in black men.

Association of testis derived transcript gene variants and prostate cancer risk. Publishing Authors By Initials

X Liu,MS Cicek,SJ Plummer,E Jorgenson,G Casey,JS Witte,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

PUBMED ID PMID:

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Association of testis derived transcript gene variants and prostate cancer risk. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of urology

VOLUME: 177

Page Numbers: 894-8

Journal Abbreviation: J. Urol.

ISSN: 0022-5347

DAY: 3

MONTH: Mar

YEAR: 2007

Association of testis derived transcript gene variants and prostate cancer risk. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376374

Association of testis derived transcript gene variants and prostate cancer risk. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: genetics

Chemical & Substance for Abstract: Association of testis derived transcript gene variants and prostate cancer risk. Information

Substance Name: Tumor Suppressor Proteins

Registry Number: 0

Grant and Affiliation Information for Association of testis derived transcript gene variants and prostate cancer risk.

AFFILIATION: Department of Epidemiology and Biostatistics, and Institute for Human Genetics, University of California, San Francisco, San Francisco, California 94143-0794, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA98683

ACRONYM: CA

MEDLINETA: J Urol

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Number Hits: 0

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