Association of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with kawasaki disease and coronary involvement.

Association of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with kawasaki disease and coronary involvement. Research Abstract Details 

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Association of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with kawasaki disease and coronary involvement. Abstract Text:

Naokata Sumitomo,Kensuke Karasawa,Kazuo Taniguchi,Rie Ichikawa,Junji Fukuhara,Osamu Abe,Michio Miyashita,Hiroshi Kanamaru,Mamoru Ayusawa,Kensuke Harada,Naokata Sumitomo,Kensuke Karasawa,Kazuo Taniguchi,Rie Ichikawa,Junji Fukuhara,Osamu Abe,Michio Miyashita,Hiroshi Kanamaru,Mamoru Ayusawa,Kensuke Harada,

Background This study was performed to investigate the incidence of arrhythmias in patients with Kawasaki disease (KD). Methods and Results Electrophysiologic studies (EPS) were performed in 40 patients (mean age: 10.3+/-5.1 years; 30 males, 10 females) with KD who had severe to moderate coronary artery disease. Clinical arrhythmias were documented in 4 patients (premature ventricular contractions, ventricular tachycardia, atrioventricular block, and ventricular fibrillation). Dual atrioventricular nodal pathways were demonstrated in 3 patients. Nonsustained atrial fibrillation was induced in 1 patient. The AH interval was prolonged in 2 patients. The Wenckebach rate was 164+/-37 beats/min, and 4 of the patients had a decreased Wenckebach rate. The maximum and corrected sinus node recovery times were 997+/-257 ms and 281+/-130 ms, respectively, and 7 patients were thought to be abnormal. The sino-atrial conduction time was 108+/-64 ms, and 2 patients had prolonged conduction times. Conclusions Although there was no relationship between coronary stenosis or obstruction and the EPS parameters, the incidence of abnormal sinus node and atrioventricular node function is apparently higher in KD patients than in the normal population. These functional abnormalities may possibly be caused by myocarditis or an abnormal microcirculation in the sinus node and atrioventricular node artery. In some patients, myocardial ischemia may provoke malignant ventricular arrhythmia. (Circ J 2008; 72: 274 - 280).

Association of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with kawasaki disease and coronary involvement. Publishing Authors By Initials

N Sumitomo,K Karasawa,K Taniguchi,R Ichikawa,J Fukuhara,O Abe,M Miyashita,H Kanamaru,M Ayusawa,K Harada,N Sumitomo,K Karasawa,K Taniguchi,R Ichikawa,J Fukuhara,O Abe,M Miyashita,H Kanamaru,M Ayusawa,K Harada,

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Association of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with kawasaki disease and coronary involvement. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Circulation journal : official journal of the Japa

VOLUME: 72

Page Numbers: 274-80

Journal Abbreviation: Circ. J.

ISSN: 1346-9843

DAY: 25

MONTH: Feb

YEAR: 2008

Association of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with kawasaki disease and coronary involvement. Information

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LANGUAGE: eng

NlmUniqueID: 101137683

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Grant and Affiliation Information for Association of sinus node dysfunction, atrioventricular node conduction abnormality and ventricular arrhythmia in patients with kawasaki disease and coronary involvement.

AFFILIATION: Department of Pediatrics and Pediatric Health, Nihon University School of Medicine.

Country: Japan

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MEDLINETA: Circ J

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