Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture.

Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. Abstract Text:

Fang Xie,Mallika Padival,Ruth E Siegel,

The growth factor neuregulin 1 (NRG) selectively induces an increase in the gamma-aminobutyric acid (GABA)(A) receptor beta2 subunit protein in rat cerebellar granule neurons in culture. We previously demonstrated that NRG acts by triggering ErbB4 receptor phosphorylation and subsequent signaling through the mitogen-activated kinase (MAPK), phosphatidyl inositol-3 kinase (PI-3K) and cyclin-dependent kinase 5 (cdk5) pathways. In this report we show that the scaffolding protein, PSD-95, plays a key role in mediating the effects of NRG and that reducing its level attenuates the NRG-induced increase in beta2 subunit expression. PSD-95 appears to facilitate the effects of NRG through its association with ErbB4, an interaction that is augmented by NRG-activated cdk signaling. Inhibition of cdk activity with roscovitine attenuates the association of PSD-95 with ErbB4. The effects of cdk5 are not blocked by U0126, an inhibitor of MAPK signaling, indicating that cdk5 functions independently of cross-talk with this pathway. These findings raise the possibility that NRG-induced activation of cdk5 works in part by recruiting PSD-95, a protein involved in regulating synaptic plasticity, to associate with ErbB4. This interaction may be a positive feedback loop that augments NRG signaling and its downstream effects on GABA(A) receptor beta2 subunit expression.

Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. Publishing Authors By Initials

F Xie,M Padival,RE Siegel,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

PUBMED ID PMID:

MEDLINE DATE:

Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of neurochemistry

VOLUME: 100

Page Numbers: 62-72

Journal Abbreviation: J. Neurochem.

ISSN: 0022-3042

DAY: 27

MONTH: 10

YEAR: 2006

Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985190

Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: drug effects

Chemical & Substance for Abstract: Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture. Information

Substance Name: Cyclin-Dependent Kinase 5

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture.

AFFILIATION: Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, Ohio 44106-4965, USA.

Country: England

AGENCY: United States NINDS

GRANT: NS34317

ACRONYM: NS

MEDLINETA: J Neurochem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture Related Publications

• Anti-TGF-beta2 antibody therapy inhibits postoperative resynostosis in craniosynostotic rabbits.
• Association of PSD-95 with ErbB4 facilitates neuregulin signaling in cerebellar granule neurons in culture.
• At what age can children report dependably on their asthma health status?
• Attentional modulation of receptive field structure in area 7a of the behaving monkey.
• Autoimmunity versus tolerance: can dying cells tip the balance?
• Effect of the ovulatory cycle on oviductal sperm storage in the domestic fowl.
• Effects of glossopharyngeal insufflation on cardiac function: an echocardiographic study in elite breath-hold divers.
• Fighting cancer with fitness: dietary outcomes of a randomized, controlled lifestyle change intervention in healthy African-American women.
• Hypocretin (orexin) cell loss in Parkinson's disease.
• Informatics in radiology: GridCAD: grid-based computer-aided detection system.
• Integration of hydrogels with hard and soft microstructures.
• Large germline deletions and duplication in isolated cerebral cavernous malformation patients.
• MDCT of tracheobronchial narrowing in pediatric patients.
• Mecamylamine blocks nicotine-induced enhancement of the P20 auditory event-related potential and evoked gamma.
• MedlinePlus and the challenge of low health literacy: findings from the Colonias project.
• Mortality partitions and their relevance to research on senescence.
• Onset of puberty in CD-1 mouse pups exposed prenatally through weaning to endophyte-infected tall fescue seed.
• Oxidation of 2-mercaptobenzothiazole in latex gloves and its possible haptenation pathway.
• Phage display-based molecular methods in immunohematology.
• Pharmacokinetic and behavioral characterization of a long-term antipsychotic delivery system in rodents and rabbits.
• Pneumonitis in human cytomegalovirus infection.
• Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.
• Premature carotid artery disease in long-term survivors of childhood cancer treated with neck irradiation: a series of 5 cases.
• Reproducibility of platelet function testing.
• Sexual violence inside prisons: rates of victimization.
• Stress and health: psychological, behavioral, and biological determinants.
• The effects of yoga practice on psychological well-being: 2426: board #105 june 1 3:30 PM -5:00 PM.
• The neurobiology of aggression and rage: role of cytokines.
• Trends in the inpatient mental health treatment of children and adolescents in US community hospitals between 1990 and 2000.
• Yield of brain 18F-FDG PET in evaluating patients with potentially operable non-small cell lung cancer.