Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study.

Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Research Abstract Details 

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Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Abstract Text:

James B Meigs,Martin G Larson,Caroline S Fox,John F Keaney,Ramachandran S Vasan,Emelia J Benjamin,

OBJECTIVE: Systemic oxidative stress causes insulin resistance in rodents. We tested the hypothesis that oxidative stress and insulin resistance are associated in humans. RESEARCH DESIGN AND METHODS: We used cross-sectional data from 2,002 nondiabetic subjects of the community-based Framingham Offspring Study. We measured insulin resistance with the homeostasis model and defined categorical insulin resistance as homeostasis model assessment of insulin resistance (HOMA-IR) > 75th percentile. We measured oxidative stress using the ratio of urine 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha) to creatinine and used age- and sex-adjusted regression models to test the association of oxidative stress with insulin resistance in individuals without diabetes and among subgroups at elevated risk of diabetes. RESULTS: Across 8-epi-PGF2alpha/creatinine tertiles, the prevalence of insulin resistance increased (18.0, 27.5, and 29.4% for the first, second, and third tertiles, respectively; P < 0.0001), as did mean levels of HOMA-IR (3.28, 3.83, and 4.06 units; P < 0.0001). The insulin resistance-oxidative stress association was attenuated by additional adjustment for BMI (P = 0.06 across tertiles for insulin resistance prevalence; P = 0.004 for mean HOMA-IR). Twenty-six percent of participants were obese (BMI > or = 30 kg/m2), 39% had metabolic syndrome (according to the Adult Treatment Panel III definition), and 37% had impaired fasting glucose (IFG) (fasting glucose 5.6-6.9 mmol/l). Among 528 obese participants, respectively, insulin resistance prevalence was 41.3, 60.6, and 54.2% across 8-epi-PGF2alpha/creatinine tertiles (P = 0.005); among 781 subjects with metabolic syndrome, insulin resistance prevalence was 41.3, 56.7, and 51.7% (P = 0.0025); and among 749 subjects with IFG, insulin resistance prevalence was 39.6, 47.2, and 51.6% (P = 0.04). CONCLUSIONS: Systemic oxidative stress is associated with insulin resistance in individuals at average or elevated risk of diabetes even after accounting for BMI.

Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Publishing Authors By Initials

JB Meigs,MG Larson,CS Fox,JF Keaney,RS Vasan,EJ Benjamin,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research

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Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Diabetes care

VOLUME: 30

Page Numbers: 2529-35

Journal Abbreviation: Diabetes Care

ISSN: 1935-5548

DAY: 22

MONTH: 06

YEAR: 2007

Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7805975

Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Keywords Mesh Terms:

KEYWORDS: Prevalence

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Information

Substance Name: Creatinine

Registry Number: 60-27-5

Grant and Affiliation Information for Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study.

AFFILIATION: General Medicine Division and Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA. jmeigs@partners.org

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HC-25195

ACRONYM: HC

MEDLINETA: Diabetes Care

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