Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.

Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples. Research Abstract Details 

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Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples. Abstract Text:

Aim: To investigate the possible correlation of nucleophosmin/B23 expression with bladder carcinoma recurrence. Methods: Surgically-resected bladder tumors staged pTa to pT4 were examined for nucleophosmin/B23 expression by immuno-histochemistry. The study group consisted of 132 consecutive patients surgically treated at Chang Gung Memorial Hospital between December 1998 and November 1999. The mean follow up was 72 months (range: 48-84 months). Results: Nuclear nucleophosmin/B23 staining was detected in 96% of advanced stage and poorly-differentiated tumors. Higher nucleophosmin/B23 levels were linked to more advanced tumor stages, grades, poor prognosis, and likelihood of recurrence (P<0.05). The Cox multivariate analysis indicated the nucleophosmin/B23 expression as an independent indicator for tumor recurrence (P=0.009). Conclusion: The results suggest that nucleophosmin/B23 is a favorable prognostic indicator for bladder cancer. Nucleophosmin/B23 could be a useful molecular tumor marker for predicting bladder cancer recurrence.

Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples. Publishing Authors By Initials

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Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta pharmacologica Sinica

VOLUME: 29

Page Numbers: 364-70

Journal Abbreviation: Acta Pharmacol. Sin.

ISSN: 1671-4083

DAY: 26

MONTH: Mar

YEAR: 2008

Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Association of nucleophosmin/B23 with bladder cancer recurrence based on immunohistochemical assessment in clinical samples.

AFFILIATION: Chang Gung Bioinformatics Center, Departments of Urology, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kwei-Shan, Taiwan, China. byung@mail.cgu.edu.tw.

Country: China

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MEDLINETA: Acta Pharmacol Sin

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