Association of nuclear pore FG-repeat domains to NTF2 import and export complexes.

Association of nuclear pore FG-repeat domains to NTF2 import and export complexes. Research Abstract Details 

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Association of nuclear pore FG-repeat domains to NTF2 import and export complexes. Abstract Text:

Timothy A Isgro,Klaus Schulten,

Transport into and out of the nucleus is regulated by the nuclear pore complex. Vital to this regulation are nuclear pore proteins with FG sequence repeats, which have been shown to be crucial for cell viability and which interact with nuclear transport receptors. Here we use molecular dynamics simulations to investigate the binding of FG-repeat peptides to the surface of NTF2, the Ran importer. The simulations, covering over 254 ns, agree with previous X-ray, mutational, NMR, and computational data in identifying four binding spots. They also serve to provide an all-atom view of binding at each spot, whereas FG-repeat binding has been only directly observed at a single spot. Furthermore, the simulations identify two novel binding spots in addition to the four others. All six binding spots broadly form a stripe across the surface of NTF2. The resulting regularity and proximity of binding spots on the surface may be necessary for identification of the transport receptor by the FG-repeats in the nuclear pore complex and for the successful transit of NTF2 through the pore.

Association of nuclear pore FG-repeat domains to NTF2 import and export complexes. Publishing Authors By Initials

TA Isgro,K Schulten,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Association of nuclear pore FG-repeat domains to NTF2 import and export complexes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of molecular biology

VOLUME: 366

Page Numbers: 330-45

Journal Abbreviation: J. Mol. Biol.

ISSN: 0022-2836

DAY: 18

MONTH: 11

YEAR: 2006

Association of nuclear pore FG-repeat domains to NTF2 import and export complexes. Information

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LANGUAGE: eng

NlmUniqueID: 2985088

Association of nuclear pore FG-repeat domains to NTF2 import and export complexes. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: genetics

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Substance Name: Solutions

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Grant and Affiliation Information for Association of nuclear pore FG-repeat domains to NTF2 import and export complexes.

AFFILIATION: Department of Physics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

Country: England

AGENCY: United States NCRR

GRANT: P41 RR 05969

ACRONYM: RR

MEDLINETA: J Mol Biol

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