Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children.

Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children. Research Abstract Details 

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Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children. Abstract Text:

Szilvia Bokor,Katalin Csernus,Eva Erhardt, Burus, , Decsi,Szilvia Bokor,Katalin Csernus,Eva Erhardt,István Burus,Dénes Molnár,Tamás Decsi,

AIM: To investigate the association of plasma fatty acids with the -866 G/A polymorphism of uncoupling protein 2 (UCP2) in obese children. METHODS: Fatty acid composition of plasma phospholipids and sterol esters were investigated in 80 obese children. RESULTS: Values of dihomo-gamma-linolenic acid (C20:3n-6) were significantly lower in children with the -866 A/A (n = 12) than in those with the -866 G/A (n = 34) or -866 G/G (n = 34) genotype in plasma phospholipids (3.01 [0.42] vs. 3.56 [1.02] vs. 3.53 [0.84], % weight/weight, median [interquartile range], p < 0.05), and were significantly lower in children with the -866 A/A genotype than in the other two groups in plasma sterol esters (0.73 [0.22] vs. 0.92 [0.23] vs. 0.94 [0.25], p < 0.05). Phospholipid C20:3n-6 and arachidonic acid (C20:4n-6) values showed only in children with the -866 G/G and -866 G/A genotypes significant positive correlations with plasma insulin concentrations. CONCLUSIONS: Significantly lower values of C20:3n-6 can be detected in obese children with the homozygous (-866 A/A) mutation of UCP2 than in equally obese children with heterozygous mutation or the normal genotype. High glucose-stimulated insulin response is associated with high plasma C20:3n-6 and C20:4n-6 values only in obese children with the G allele of the -866 G/A polymorphism.

Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children. Publishing Authors By Initials

S Bokor,K Csernus,E Erhardt,I Burus,D ,T Decsi,S Bokor,K Csernus,E Erhardt,I Burus,D Molnár,T Decsi,

For similar lipids: membrane lipids: phospholipids research abstracts see: lipids: membrane lipids: phospholipids research

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Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta paediatrica (Oslo, Norway : 1992)

VOLUME: 96

Page Numbers: 1350-4

Journal Abbreviation: Acta Paediatr.

ISSN: 0803-5253

DAY: 30

MONTH: Sep

YEAR: 2007

Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children. Information

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LANGUAGE: eng

NlmUniqueID: 9205968

Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children. Keywords Mesh Terms:

KEYWORDS: Phospholipids

MESH TERMS: blood

Chemical & Substance for Abstract: Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children. Information

Substance Name: Arachidonic Acid

Registry Number: 506-32-1

Grant and Affiliation Information for Association of n-6 long-chain polyunsaturated fatty acids to -866 G/A genotypes of the human uncoupling protein 2 gene in obese children.

AFFILIATION: Department of Paediatrics, University of Pécs, Pécs, Hungary.

Country: Norway

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MEDLINETA: Acta Paediatr

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