Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients: the Japan dialysis outcomes and practice patterns study.

Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients: the Japan dialysis outcomes and practice patterns study. Research Abstract Details 

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Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients: the Japan dialysis outcomes and practice patterns study. Abstract Text:

Naoki Kimata,Justin M Albert,Takashi Akiba,Shin Yamazaki,Yoshindo Kawaguchi,Shunichi Fukuhara,Tadao Akizawa,Akira Saito,Yasushi Asano,Kiyoshi Kurokawa,Ronald L Pisoni,Friedrich K Port,Naoki Kimata,Justin M Albert,Takashi Akiba,Shin Yamazaki,Yoshindo Kawaguchi,Shunichi Fukuhara,Tadao Akizawa,Akira Saito,Yasushi Asano,Kiyoshi Kurokawa,Ronald L Pisoni,Friedrich K Port,

Abnormalities in mineral metabolism have been linked to mortality in hemodialysis (HD) patients. We postulated that these abnormalities would have a particularly large deleterious impact on deaths due to cardiovascular causes in Japan. This study describes the recent status of abnormal mineral metabolism, significant predictors, and potential consequences in the Dialysis Outcomes and Practice Patterns Study (DOPPS), Phases 1 and 2, in Japan. Major predictor variables were patient demographics, comorbidities, and laboratory markers of mineral metabolism such as albumin-adjusted serum calcium (calciumAlb), phosphorus, and intact PTH (iPTH). In a cross section of 3973 Japanese HD patients in DOPPS I and II, a large faction had laboratory values outside of the recommended Kidney Disease Outcomes Quality Initiative (K/DOQI) guideline range for serum concentrations of phosphorus (51% of patients above upper target range), calciumAlb (43.7% above), calcium-phosphorus (Ca x P) product (41.1% above), and iPTH (18.6% above). All-cause mortality was significantly and independently associated with calciumAlb (relative risk [RR]=1.22 per 1 mg/dL, p=0.0005) and iPTH (RR=1.04 per 100 pg/mL, p=0.04). Cardiovascular mortality was significantly associated with calciumAlb (RR=1.28, p=0.02), phosphorus (RR=1.13 per 1 mg/dL, p=0.008), Ca x P product (RR=1.07 per 2 mg(2)/dL(2), p=0.002), and PTH (RR=1.08, p=0.0001). This study expands our understanding of the relationship between altered mineral metabolism and mortality outcomes, showing slightly stronger associations with cardiovascular causes than observed for all-cause mortality. These findings have important therapeutic implications for Japanese HD patients.

Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients: the Japan dialysis outcomes and practice patterns study. Publishing Authors By Initials

N Kimata,JM Albert,T Akiba,S Yamazaki,Y Kawaguchi,S Fukuhara,T Akizawa,A Saito,Y Asano,K Kurokawa,RL Pisoni,FK Port,N Kimata,JM Albert,T Akiba,S Yamazaki,Y Kawaguchi,S Fukuhara,T Akizawa,A Saito,Y Asano,K Kurokawa,RL Pisoni,FK Port,

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Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients: the Japan dialysis outcomes and practice patterns study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hemodialysis international. International Symposiu

VOLUME: 11

Page Numbers: 340-8

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ISSN: 1492-7535

DAY: 19

MONTH: Jul

YEAR: 2007

Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients: the Japan dialysis outcomes and practice patterns study. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Association of mineral metabolism factors with all-cause and cardiovascular mortality in hemodialysis patients: the Japan dialysis outcomes and practice patterns study.

AFFILIATION: Kidney Center, Division of Blood Purification, Tokyo Women's Medical University, Tokyo, Japan.

Country: Canada

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MEDLINETA: Hemodial Int

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