Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study.

Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Research Abstract Details 

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Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Abstract Text:

BACKGROUND: Major depressive disorder (MDD) has been linked to inflammation, but this association may be due to common precursors to both depression and inflammation. Myeloperoxidase (MPO) is an inflammatory enzyme produced by activated leukocytes that predicts risk of coronary heart disease. We sought to examine whether MPO and other markers of inflammation are associated with MDD and whether the association is confounded by genetic or other shared familial factors. METHODS: We examined 178 monozygotic and dizygotic middle-aged male twin pairs. We assessed MDD with the Structured Clinical Interview for DSM-IV. Blood markers of inflammation included MPO, interleukin-6, white blood cell count, C-reactive protein, tumor necrosis factor (TNF)-alpha, the TNF-alpha soluble receptor II, and fibrinogen. Analyses were conducted in the overall sample and among 67 twin pairs discordant for MDD using mixed effects regression. RESULTS: Twins with a history of MDD had 32% higher levels of MPO (p < .0001); this difference persisted after adjusting for other risk factors. Among dizygotic MDD-discordant twin pairs, twins with MDD had 77% higher MPO than their brothers without MDD, after adjusting for other factors (p < .0001). In contrast, no significant association was found in monozygotic twins (p = .13). Similar, but weaker, associations were found between MDD and other inflammatory biomarkers. CONCLUSIONS: Myeloperoxidase is a useful biomarker of immune activation in MDD. However, the association between inflammation and MDD is largely due to common genetic liability. Our results are consistent with the hypothesis that genes promoting inflammation are involved in the pathogenesis of MDD.

Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Publishing Authors By Initials

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Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological psychiatry

VOLUME: 64

Page Numbers: 476-83

Journal Abbreviation: Biol. Psychiatry

ISSN: 1873-2402

DAY: 2

MONTH: 06

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia.

Country: United States

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MEDLINETA: Biol Psychiatry

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