Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients.

Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients. Research Abstract Details 

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Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients. Abstract Text:

Souvik Sen,Alan Hinderliter,Pranab K Sen,Jennifer Simmons,Vicky A LeGrys,James Beck,Steven Offenbacher,Kevin Moss,Stephen M Oppenheimer,

BACKGROUND AND PURPOSE: Leukocyte count is an independent predictor of stroke. We investigated the association between leukocyte count and progression of aortic atheroma over 12 months in stroke/transient ischemic attack (TIA) patients. METHODS: Consecutive ischemic stroke and transient ischemic attack patients underwent 12-month sequential transesophageal echocardiography and were assessed for total and differential leukocyte counts on admission. Paired aortic plaque images were assessed for several parameters, including changes in grade, intimal-medial thickness (IMT), and cross-sectional area. Multivariate linear and logistic regressions were used to calculate the effect of leukocyte count on the change in aortic atheromas over 12 months. RESULTS: Of the 115 participants (mean+/-SD age, 64.6+/-11.9 years; 53.1% men; 73.4% white, 24.2% black, and 2.3% Asian), 45 (35%) showed clinically significant progression of aortic atheromas (maximal change in IMT >0.70 mm over 12 months). The mean admission leukocyte count was higher in the progression group compared with the no-progression group (8.6+/-2.2 vs 7.3+/-2.2 x 10(9)/L respectively, P=0.002). Each unit increase in leukocyte count was associated with a 0.26-mm increase in aortic arch IMT over 12 months (P=0.006). After adjustment for other atherosclerosis risk factors, the relation persisted (mean increase in aortic arch IMT per unit increase in leukocyte count=0.27 mm, P=0.007). Each unit increase in leukocyte count was associated with an increased risk of significant progression of aortic atheromas (adjusted odds ratio=1.33; 95% CI, 1.09 to 1.61). CONCLUSIONS: In stroke/transient ischemic attack patients, leukocyte count is independently associated with the progression of aortic atheroma over 12 months (>0.70 mm), which is associated with cardiovascular risk.

Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients. Publishing Authors By Initials

S Sen,A Hinderliter,PK Sen,J Simmons,VA LeGrys,J Beck,S Offenbacher,K Moss,SM Oppenheimer,

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Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Stroke; a journal of cerebral circulation

VOLUME: 38

Page Numbers: 2900-5

Journal Abbreviation: Stroke

ISSN: 1524-4628

DAY: 27

MONTH: 09

YEAR: 2007

Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients. Information

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LANGUAGE: eng

NlmUniqueID: 235266

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Grant and Affiliation Information for Association of leukocyte count with progression of aortic atheroma in stroke/transient ischemic attack patients.

AFFILIATION: Department of Neurology, University of North Carolina, Chapel Hill, NC, USA. SenS@neurology.unc.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR00046

ACRONYM: RR

MEDLINETA: Stroke

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