Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample.

Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Research Abstract Details 

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Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Abstract Text:

Arpana Agrawal,Howard J Edenberg,Tatiana Foroud,Laura J Bierut,Gerald Dunne,Anthony L Hinrichs,John I Nurnberger,Raymond Crowe,Samuel Kuperman,Marc A Schuckit,Henri Begleiter,Bernice Porjesz,Danielle M Dick,

Results from twin studies suggest that overlapping genetic factors influence alcohol dependence and illicit drug dependence. Using data from the Collaborative Study on the Genetics of Alcoholism (COGA), we examined the association between 69 SNPs in the GABAA receptor gene cluster on chromosome 4 and marijuana and illicit drug dependence, individually, and as co-occurring phenotypes with alcohol dependence. Results suggested association between marijuana dependence and illicit drug dependence with SNPs in the GABRA2 gene. Interestingly, the evidence for association previously observed with alcohol dependence came only from individuals with comorbid illicit drug dependence. There was no association with other genes in the GABAA cluster on chromosome 4 with illicit drug dependence.

Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Publishing Authors By Initials

A Agrawal,HJ Edenberg,T Foroud,LJ Bierut,G Dunne,AL Hinrichs,JI Nurnberger,R Crowe,S Kuperman,MA Schuckit,H Begleiter,B Porjesz,DM Dick,

For similar disorders of environmental origin: substance-related disorders research abstracts see: disorders of environmental origin: substance-related disorders research

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Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Behavior genetics

VOLUME: 36

Page Numbers: 640-50

Journal Abbreviation: Behav. Genet.

ISSN: 0001-8244

DAY: 3

MONTH: Sep

YEAR: 2006

Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Information

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LANGUAGE: eng

NlmUniqueID: 251711

Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Keywords Mesh Terms:

KEYWORDS: Substance-Related Disorders

MESH TERMS: genetics

Chemical & Substance for Abstract: Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Association of GABRA2 with drug dependence in the collaborative study of the genetics of alcoholism sample.

AFFILIATION: Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, USA.

Country: United States

AGENCY: United States NIAAA

GRANT: U10AA08401

ACRONYM: AA

MEDLINETA: Behav Genet

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