Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing.

Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing. Research Abstract Details 

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Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing. Abstract Text:

Pamela N Peterson,David J Magid,Colleen Ross,P Michael Ho,John S Rumsfeld,Michael S Lauer,Ella E Lyons,Scott S Smith,Frederick A Masoudi,Pamela N Peterson,David J Magid,Colleen Ross,P Michael Ho,John S Rumsfeld,Michael S Lauer,Ella E Lyons,Scott S Smith,Frederick A Masoudi,

BACKGROUND: Little is known about the association between exercise capacity and nonfatal cardiac events in patients referred for exercise treadmill testing (ETT). Our objective was to determine the prognostic importance of exercise capacity for nonfatal cardiac events in a clinical population. METHODS: A cohort study was performed of 9191 patients referred for ETT. Median follow-up was 2.7 years. Exercise capacity was quantified as the proportion of age- and sex-predicted metabolic equivalents achieved and categorized as less than 85%, 85% to 100%, and greater than 100%. Individual primary outcomes were myocardial infarction, unstable angina, and coronary revascularization. All-cause mortality was a secondary outcome. RESULTS: Patients with lower exercise capacity were more likely to be female (55.38% vs 42.62%); to have comorbidities such as diabetes (23.16% vs 9.61%) and hypertension (59.43% vs 44.05%); and to have abnormal ETT findings such as chest pain on the treadmill (12.09% vs 7.63%), abnormal heart rate recovery (82.74% vs 64.13%), and abnormal chronotropic index (32.89% vs 12.20%). In multivariable analysis, including other ETT variables, lower exercise capacity (< 85% of predicted) was associated with increased risk of myocardial infarction (hazard ratio [HR], 2.36; 95% confidence interval [CI], 1.55-3.60), unstable angina (HR, 2.39; 95% CI, 1.78-3.21), coronary revascularization (HR, 1.75; 95% CI, 1.46- 2.08), and all-cause mortality (HR, 2.90; 95% CI, 1.88-4.47) compared with exercise capacity greater than 100% of predicted. CONCLUSION: Adjusting for patient characteristics and other ETT variables, reduced exercise capacity was associated with both nonfatal cardiovascular events and mortality in patients referred for ETT.

Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing. Publishing Authors By Initials

PN Peterson,DJ Magid,C Ross,PM Ho,JS Rumsfeld,MS Lauer,EE Lyons,SS Smith,FA Masoudi,PN Peterson,DJ Magid,C Ross,PM Ho,JS Rumsfeld,MS Lauer,EE Lyons,SS Smith,FA Masoudi,

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Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of internal medicine

VOLUME: 168

Page Numbers: 174-9

Journal Abbreviation: Arch. Intern. Med.

ISSN: 0003-9926

DAY: 28

MONTH: Jan

YEAR: 2008

Association of exercise capacity on treadmill with future cardiac events in patients referred for exercise testing. Information

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LANGUAGE: eng

NlmUniqueID: 372440

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AFFILIATION: MSPH, Division of Cardiology, Department of Medicine, Denver Health Medical Center, Mail Code 0960, 777 Bannock St, Denver, CO 80204. Pamela.Peterson@uchsc.edu.

Country: United States

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MEDLINETA: Arch Intern Med

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