Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents.

Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Research Abstract Details 

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Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Abstract Text:

Steve S Lee,Benjamin B Lahey,Irwin Waldman,Carol A Van Hulle,Paul Rathouz,William E Pelham,Jan Loney,Edwin H Cook,

Associations between dopamine transporter (DAT1) variable number tandem repeats (VNTR), genotypes, and disruptive behavior were examined in an 8-year longitudinal study of children (n = 183). Half of the children met criteria for attention-deficit/hyperactivity disorder (ADHD) at 4-6 years and half were non-referred comparison children. Consistent with several studies, the non-additive association for the 10-repeat allele was significant for hyperactivity-impulsivity (HI) symptoms. However, consistent with other studies, exploratory analyses of the non-additive association of the 9-repeat allele of DAT1 with HI and oppositional defiant disorder (ODD) symptoms also were significant. The inconsistent association between DAT1 and child behavior problems in this and other samples may reflect joint influence of the 10-repeat and 9-repeat alleles.

Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Publishing Authors By Initials

SS Lee,BB Lahey,I Waldman,CA Van Hulle,P Rathouz,WE Pelham,J Loney,EH Cook,

For similar genetic phenomena: variation (genetics): polymorphism, genetic research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic research

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Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of medical genetics. Part B, Neur

VOLUME: 144

Page Numbers: 310-7

Journal Abbreviation: Am. J. Med. Genet. B Neuropsyc

ISSN: 1552-4841

DAY: 5

MONTH: Apr

YEAR: 2007

Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101235742

Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Genetic

MESH TERMS: genetics

Chemical & Substance for Abstract: Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents. Information

Substance Name: SLC6A3 protein, human

Registry Number: 0

Grant and Affiliation Information for Association of dopamine transporter genotype with disruptive behavior disorders in an eight-year longitudinal study of children and adolescents.

AFFILIATION: Department of Psychology, University of California, Los Angeles, California 90095-1563, USA. stevelee@psych.ucla.edu

Country: United States

AGENCY: United States NIMH

GRANT: 2R01 MH053554

ACRONYM: MH

MEDLINETA: Am J Med Genet B Neuropsychiat

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