Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus.

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Abstract Text:

OBJECTIVE: To explore the association of antibodies directed against N-methyl-D-aspartate receptor subunit NR2 (anti-NR2) in cerebrospinal fluid (CSF) with neuropsychiatric manifestations in systemic lupus erythematosus (NPSLE). METHODS: Paired serum and CSF specimens were obtained from 56 patients with NPSLE (38 with diffuse psychiatric/neuropsychological syndromes [diffuse NPSLE] and 18 with neurologic syndromes or peripheral neuropathy [focal NPSLE]) and from 20 control patients with noninflammatory neurologic diseases. IgG anti-NR2 antibodies were measured by enzyme-linked immunosorbent assay using synthetic peptide containing the extracellular ligand-binding domain of NR2. The binding of affinity-purified anti-NR2 to human neuroblastoma cell line SK-N-MC was examined by flow cytometry. RESULTS: Purified anti-NR2 bound to the surface of SK-N-MC cells. Levels of anti-NR2 antibodies in CSF were significantly elevated in patients with diffuse NPSLE compared with levels in control patients or those with focal NPSLE, whereas there were no significant differences in serum anti-NR2 levels among the 3 groups. In 31 of the 38 patients with diffuse NPSLE (81.6%) and 8 of the 18 patients with focal NPSLE (44.4%), CSF anti-NR2 levels were more than 3 SD above the mean level in the control patients (P=0.0120 by chi-square test). CONCLUSION: These results indicate that anti-NR2 is a constituent of antineuronal antibodies and, more importantly, that anti-NR2 antibodies in CSF, but not in serum, are associated with diffuse NPSLE.

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Arthritis and rheumatism

VOLUME: 58

Page Numbers: 1130-5

Journal Abbreviation: Arthritis Rheum.

ISSN: 0004-3591

DAY: 22

MONTH: Apr

YEAR: 2008

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370605

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus.

AFFILIATION: Teikyo University School of Medicine, Tokyo, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Arthritis Rheum

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus Related Publications

• A metastatic adenocarcinoma of lung simulating humeral head osteonecrosis.
• Anatomical study on the menisco-femoral ligaments of the knee.
• Association of cerebrospinal fluid anti-NR2 glutamate receptor antibodies with diffuse neuropsychiatric systemic lupus erythematosus.
• Bone and joint lesions associated with pustulosis palmaris et plantaris. A clinical and histological study.
• Bone cell activities and calcium-regulating hormones.
• Correct citation regarding interleukin-6 levels in cerebrospinal fluid from patients with neuropsychiatric lupus: comment on the article by Fragoso-Loyo et al.
• Decreased numbers of T gamma lymphocytes in rheumatoid synovial membrane.
• Distribution of neural elements in collateral ligaments of the rat knee joint--light and electron microscopic studies using silver impregnation method and cholinesterase histochemistry.
• Dumbbell-shaped spinal extradural hemangioma.
• EMG biofeedback in tendon transplantation for foot drop.
• Effect of intramedullary bone cement fixation on fracture healing.
• Enhanced Production of IgE Anti-Japanese Cedar Pollen Specific Antibodies by Peripheral Blood B Cells from Patients with Japanese Cedar Pollinosis.
• Genu recurvatum: a complication of prolonged femoral skeletal traction.
• Histopathology of central nervous system lesions in Behçet's disease.
• Interaction of macrophages with rheumatoid articular cartilage.
• Light microscopic and electron microscopic studies of individual cells in pigmented villonodular synovitis and bursitis (Jaffé).
• Osteogenic potential of hematoma in fracture healing--transplantation of hematoma under the periosteum of the parietal bone.
• Partial splenic embolization prior to combination therapy of interferon and ribavirin in chronic hepatitis C patients with thrombocytopenia.
• Peroneal nerve palsy due to fabella.
• Studies on bromelain. II. Its activation and fractionation.
• The osteogenetic potential of fracture haematoma. Subperiosteal and intramuscular transplantation of the haematoma.
• The response of osteocytes to a lipid clearing agent in steroid-treated rabbits.
• Vertebral compression fracture following segmental spinal instrumentation.
• Weakness of thigh muscles in individuals sustaining anterior cruciate ligament injury.