Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise.

Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Research Abstract Details 

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Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Abstract Text:

BACKGROUND: Physical fitness may attenuate the increased atherosclerotic risk in patients with systemic hypertension. We investigated the association of screening blood pressure (BP) and cardiorespiratory fitness with baseline levels and exercise-induced changes in levels of soluble atherosclerotic risk markers. METHODS: Twenty-six otherwise healthy and unmedicated subjects with elevated BP (systolic BP and/or diastolic BP > or =130/85 mm Hg) and 40 subjects with normal BP underwent 20-min treadmill exercise at 65% to 70% of predetermined peak oxygen consumption (VO(2peak)). Interleukin (IL)-6, soluble intercellular adhesion molecule (sICAM)-1, von Willebrand factor (VWF) antigen, and plasminogen activator inhibitor (PAI)-1 antigen were measured at baseline (ie, pre-exercise), early postexercise, and late postexercise (ie, 25 min after exercise). RESULTS: At baseline, higher screening mean arterial BP (MAP) independently predicted higher sICAM-1 levels (P = .031), and lower VO(2peak) independently predicted higher IL-6 (P = .016) and PAI-1 (P < .001) levels. Early and late postexercise lower VO(2peak) was associated with higher mean PAI-1 (P < or = .072) and IL-6 (P < or = .026) levels, and higher screening MAP was associated with higher mean sICAM-1 levels (P < or = .035). Higher VO(2peak) was associated with a greater PAI-1 increase from baseline to early postexercise in subjects with elevated BP (P = .045) but not in those with normal BP. CONCLUSIONS: Circulating levels of some atherosclerotic risk markers at baseline and with exercise were higher with elevated BP and lower with better fitness. Greater fitness did not particularly protect subjects with elevated BP from potentially harmful responses of atherosclerotic risk markers to acute physical exercise.

Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Publishing Authors By Initials

For similar proteins: blood proteins: blood coagulation factors: von willebrand factor research abstracts see: proteins: blood proteins: blood coagulation factors: von willebrand factor research

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Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of hypertension : journal of the

VOLUME: 20

Page Numbers: 670-5

Journal Abbreviation: Am. J. Hypertens.

ISSN: 0895-7061

DAY: 3

MONTH: Jun

YEAR: 2007

Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803676

Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Keywords Mesh Terms:

KEYWORDS: von Willebrand Factor

MESH TERMS: metabolism

Chemical & Substance for Abstract: Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise. Information

Substance Name: Intercellular Adhesion Molecule-1

Registry Number: 126547-89-5

Grant and Affiliation Information for Association of blood pressure and fitness with levels of atherosclerotic risk markers pre-exercise and post-exercise.

AFFILIATION: Division of General Internal Medicine and Cardiovascular Prevention and Rehabilitation, Swiss Cardiovascular Center Berne, Department of Cardiology, University Hospital Berne, Berne, Switzerland.

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL-57265-05

ACRONYM: HL

MEDLINETA: Am J Hypertens

REFSOURCE: Am J Hypertens. 2007 Jun;20(6):676-7

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