Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population.

Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. Research Abstract Details 

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Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. Abstract Text:

Seung-Hun Cha,Hung-Tae Kim,Yangsoo Jang,Sungha Park,Jae-Jung Kim,Min Young Song,Jin-Hyoung Park,Ha-Jung Ryu,Hyun-Young Park,Sung-Joo Kim Yoon,Kuchan Kimm,Jong-Keuk Lee,Bermseok Oh,Seung-Hun Cha,Hung-Tae Kim,Yangsoo Jang,Sungha Park,Jae-Jung Kim,Min Young Song,Jin-Hyoung Park,Ha-Jung Ryu,Hyun-Young Park,Sung-Joo Kim Yoon,Kuchan Kimm,Jong-Keuk Lee,Bermseok Oh,

OBJECTIVE: Coronary artery disease is caused by multiple genetic and environmental factors. The disease is also closely associated with cardiovascular conditions such as hypertension. In order to investigate any possible role of hypertension candidate genes in the disease development and progression, we examined the association of the polymorphisms of 31 hypertension candidate genes with coronary artery disease. METHODS: Genetic polymorphisms of 31 hypertension candidate genes were initially screened by resequencing DNA samples from 24 unrelated individuals in a Korean population. Association analysis was performed using 1284 unrelated Korean men, including 749 coronary artery disease subjects and 535 normal healthy controls. RESULTS: We identified a total of 409 single nucleotide polymorphisms including 40 nonsynonymous single nucleotide polymorphisms, 32 insertions/deletions and four microsatellites. Among 40 nonsynonymous single nucleotide polymorphisms, 29 were examined for an association with coronary artery disease. A significant association with coronary artery disease was observed in a polymorphism of the ADD1 gene (Gly460Trp; +29017G/T) (odds ratio 0.71-0.81; P = 0.01-0.04). The same polymorphism was also associated with the number of arteries with significant coronary artery stenosis in the coronary artery disease patients (P = 0.01) as well as the increase in systolic blood pressure (P = 0.02). CONCLUSIONS: The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.

Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. Publishing Authors By Initials

SH Cha,HT Kim,Y Jang,S Park,JJ Kim,MY Song,JH Park,HJ Ryu,HY Park,SJ Yoon,K Kimm,JK Lee,B Oh,SH Cha,HT Kim,Y Jang,S Park,JJ Kim,MY Song,JH Park,HJ Ryu,HY Park,SJ Yoon,K Kimm,JK Lee,B Oh,

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Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of hypertension

VOLUME: 25

Page Numbers: 2413-20

Journal Abbreviation: J. Hypertens.

ISSN: 0263-6352

DAY: 6

MONTH: Dec

YEAR: 2007

Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population. Information

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LANGUAGE: eng

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AFFILIATION: National Genome Research Institute, National Institute of Health, Seoul, Seoul, Korea.

Country: England

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MEDLINETA: J Hypertens

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