Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents.

Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents. Research Abstract Details 

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Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents. Abstract Text:

Joanna Koenigsberg,Gillian S Boyd,Samuel S Gidding,Sandra G Hassink,Bonita Falkner,

To determine the effect of age and sex on cardiovascular risk factor expression in overweight children, data from clinical records of 497 overweight children (2-18 years of age) were examined. Data included average blood pressure (BP), fasting lipids, glucose, and insulin. The sample was stratified by age (younger than 11 and 11 years and older) and analyzed by sex. Subjects with an average BP > or = 90th percentile were classified as having high BP. Insulin and glucose were used in equations to estimate insulin sensitivity. Among subjects 11 years and older (n = 268), 52.6% of males had high BP compared with 32.6% of females (P < .001). Mean high-density lipoprotein cholesterol was lowest in the males 11 years and older compared with the females and younger males (P < .01). Triglyceride levels trended higher in males independent of age. In multivariate analyses, high BP was most strongly associated with age and severity of overweight while triglyceride level was most associated with sex and insulin resistance. The prevalence of high BP and dyslipidemia in overweight children is high. Overweight males 11 years and older have a higher prevalence of high BP and low high-density lipoprotein cholesterol than females and younger males. Greater cardiovascular risk factor expression in overweight males 11 years and older may explain the earlier appearance of cardiovascular disease end points in overweight men.

Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents. Publishing Authors By Initials

J Koenigsberg,GS Boyd,SS Gidding,SG Hassink,B Falkner,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

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Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the cardiometabolic syndrome

VOLUME: 1

Page Numbers: 253-8

Journal Abbreviation:

ISSN: 1559-4564

DAY: 3

MONTH: 12

YEAR: 2006

Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101284690

Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: blood

Chemical & Substance for Abstract: Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents. Information

Substance Name: Insulin

Registry Number: 11061-68-0

Grant and Affiliation Information for Association of age and sex with cardiovascular risk factors and insulin sensitivity in overweight children and adolescents.

AFFILIATION: Department of Medicine, Thomas Jefferson University, Philadelphia, PA, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL051547

ACRONYM: HL

MEDLINETA: J Cardiometab Syndr

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