Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.

Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Research Abstract Details 

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Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Abstract Text:

Salam A Al-Attar,Rebecca L Pollex,Matthew R Ban,T Kue Young,Peter Bjerregaard,Sonia S Anand,Salim Yusuf,Bernard Zinman,Stewart B Harris,Anthony Jg Hanley,Philip W Connelly,Murray W Huff,Robert A Hegele,

BACKGROUND: The rs9939609 T>A single-nucleotide polymorphism (SNP) in the FTO gene has previously been found to be associated with obesity in European Caucasian samples. The objective of this study is to examine whether this association extends to metabolic syndrome (MetS) and applies in non-Caucasian samples. METHODS: The FTO rs9939609 SNP was genotyped in 2121 subjects from four different non-Caucasian geographical ancestries. Subjects were classified for the presence or absence of MetS according to the International Diabetes Federation (IDF) and National Cholesterol Education Program Adult Treatment Panel (NCEP ATP) III definitions. RESULTS: Carriers of > or = 1 copy of the rs9939609 A allele were significantly more likely to have IDF-defined MetS (35.8%) than non-carriers (31.2%), corresponding to a carrier odds ratio (OR) of 1.23 (95% confidence interval [CI] 1.01 to 1.50), with a similar trend for the NCEP ATP III-defined MetS. Subgroup analysis showed that the association was particularly strong in men. The association was related to a higher proportion of rs9939609 A allele carriers meeting the waist circumference criterion; a higher proportion also met the HDL cholesterol criterion compared with wild-type homozygotes. CONCLUSION: Thus, the FTO rs9939609 SNP was associated with an increased risk for MetS in this multi-ethnic sample, confirming that the association extends to non-Caucasian population samples.

Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Publishing Authors By Initials

SA Al-Attar,RL Pollex,MR Ban,TK Young,P Bjerregaard,SS Anand,S Yusuf,B Zinman,SB Harris,AJ Hanley,PW Connelly,MW Huff,RA Hegele,

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Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cardiovascular diabetology

VOLUME: 7

Page Numbers: 5

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ISSN: 1475-2840

DAY: 13

MONTH: 03

YEAR: 2008

Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample.

AFFILIATION: Vascular Biology Research Group, Robarts Research Institute, London, Ontario, Canada. salattar@robarts.ca

Country: England

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MEDLINETA: Cardiovasc Diabetol

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