Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Abstract Text:

ABSTRACT: BACKGROUND: Variation in response to the hedonic and adverse effects of a substance is in part an inherited factor that may influence its use, abuse and dependence. The mu opioid receptor is the primary site of action for opiates and individuals with polymorphisms in this receptor appear to have variation in the CNS effects of opiates. Several studies have suggested that this receptor may also mediate some of the effects of non-opioid drugs, such as alcohol. The purpose of this study was to investigate associations between 13 single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) with self-reported responses to alcohol, an endophenotype associated with the development of alcohol dependence, in American Indians living on eight contiguous reservations. METHODS: Each participant gave a blood sample and completed a structured diagnostic interview. Additionally, response to alcohol was indexed using the expectation version of the subjective high assessment scale (SHAS-E). SNPs were genotyped in 251 participants and data analyses were conducted using SOLAR. RESULTS: The estimated heritability (h2) for the SHAS-E phenotypes ranged from 0.01 to 0.28. Endorsing the expectation of a more intense response on one or more of the following items from the SHAS-E: buzzed, clumsy, dizzy, drunk, effects, high, nausea, sleepy, talkative, terrible, and/or uncomfortable after imbibing 2-3 drinks was significantly associated with having at least one minor allele for at least one of 7 SNPs (p < 0.01) in the OPRM1 receptor gene. CONCLUSION: These studies provide data to suggest that the minor allele, for most of the polymorphisms in the OPRM1 receptor gene investigated, was found to be associated with a more intense, and/or more adverse, response to alcohol, traits that are significantly correlated with lowered quantity of alcohol consumption and less susceptibility to dependence in this Indian population. These data further suggest that making conclusions on the role of the mu opiod receptor gene in the development of alcohol dependence may be limited if only one polymorphism in the gene is evaluated in isolation.

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: BMC medical genetics

VOLUME: 9

Page Numbers: 35

Journal Abbreviation: BMC Med. Genet.

ISSN: 1471-2350

DAY: 23

MONTH: 04

YEAR: 2008

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100968552

Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.

AFFILIATION: From the Departments of Molecular and Experimental Medicine and Molecular and Integrative Neurosciences, The Scripps Research Institute, La Jolla, CA, USA. cindye@scripps.edu.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: BMC Med Genet

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Association between single nucleotide polymorphisms in the mu opioid receptor gene OPRM1 and self-reported responses to alcohol in American Indians Related Publications

• A monitor for neutron flux measurements up to 20 MeV.
• Age at first intoxication and alcohol use disorders in Southwest California Indians.
• Anaerobic infections in clinical medicine. A microbiological and clinical introduction.
• Association Between Single Nucleotide Polymorphisms in the Cannabinoid Receptor Gene (CNR1) and Impulsivity in Southwest California Indians.
• Association between fibrinogen and other risk factors for cardiovascular disease in men and women. Results from the Göteborg MONICA survey 1985.
• Association between single nucleotide polymorphisms in the mu opioid receptor gene (OPRM1) and self-reported responses to alcohol in American Indians.
• Beta-blockers and plasma triglycerides.
• Closing volume in 50- and 60- year old men: (a preliminary report).
• Externalizing disorders in American Indians: comorbidity and a genome wide linkage analysis.
• Genomic screen for loci associated with alcohol dependence in Mission Indians.
• Genomic screen for substance dependence and body mass index in southwest California Indians.
• Impediments to the control of hypertension. Hypertension Management Audit Group.
• Nitrogen closing volume-test in 50- and 60- year-old men.
• Normative data for commercial pineapple juice from concentrate.
• Postoperative pain.
• Prevalence of primary and secondary hypertension: studies in a random population sample.
• Quality of life and Helicobacter pylori eradication.
• Quality of life in upper gastrointestinal disorders.
• Rapidly progressive autosomal dominant Parkinsonism and dementia with Pallido-Ponto-Nigral Gegeneration (PPND) and Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex (DDPAC) are clinically distinct conditions that are both linked to 17q21-22.
• Synergistic effects of risk factors.
• [Cancer of the rectum as labor complication.]
• [Disease anxiety among medical students and law students]
• [Hypochondriasis and cognitive therapy]
• [IRON CONTENT IN RED WINE ETC.]
• [Interferons. Biological principal and practical application]
• [Psychomotor physical therapy--patients' starting point and their evaluation of the therapeutic results]
• [Psychotherapeutic counselling via telecommunication networks]
• [Rupture of the uterus; case report.]