Association between reproductive factors and breast cancer survival in younger women.

Association between reproductive factors and breast cancer survival in younger women. Research Abstract Details 

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Association between reproductive factors and breast cancer survival in younger women. Abstract Text:

Katrina F Trivers,Marilie D Gammon,Page E Abrahamson,Mary Jo Lund,Elaine W Flagg,Jay S Kaufman,Patricia G Moorman,Jianwen Cai,Andrew F Olshan,Peggy L Porter,Louise A Brinton,J William Eley,Ralph J Coates,

This analysis investigated whether reproductive factors such as age at menarche, parity, and timing and outcomes of pregnancies were associated with survival among women with breast cancer younger than 55 years. Female residents of Atlanta, Georgia, and central New Jersey who were diagnosed with a primary, incident invasive breast cancer between 1990 and 1992 and enrolled in a population-based study (n = 1,264) were followed for 8-10 years. Detailed exposure and covariate information was collected via in-person interviews administered shortly after diagnosis. Vital status as of January 1, 2000 was ascertained through the National Death Index via the state cancer registries (n = 292 deaths). Cox regression methods were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) adjusted for confounders. Parity of 4 or more births, as compared with nulliparity, was positively associated with all-cause mortality, [HR (95% CI) = 1.71 (1.09-2.67)]. Increased mortality was associated with having given birth within 5 years prior to diagnosis (5 years) [1.78 (1.28-2.47)], and was more pronounced among women with a pre-diagnostic body mass index of <25 kg/m2 [2.54 (1.61-4.00)]. Early age at menarche and early age at first birth also modestly increased mortality; history of miscarriage, induced abortion, and ever breastfeeding were not related to survival. These results may help elucidate breast cancer progression mechanisms and enable a better understanding of how reproductive characteristics influence breast cancer survival.

Association between reproductive factors and breast cancer survival in younger women. Publishing Authors By Initials

KF Trivers,MD Gammon,PE Abrahamson,MJ Lund,EW Flagg,JS Kaufman,PG Moorman,J Cai,AF Olshan,PL Porter,LA Brinton,JW Eley,RJ Coates,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: mortality: survival rate research

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Association between reproductive factors and breast cancer survival in younger women. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Breast cancer research and treatment

VOLUME: 103

Page Numbers: 93-102

Journal Abbreviation:

ISSN: 0167-6806

DAY: 27

MONTH: 09

YEAR: 2006

Association between reproductive factors and breast cancer survival in younger women. Information

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LANGUAGE: eng

NlmUniqueID: 8111104

Association between reproductive factors and breast cancer survival in younger women. Keywords Mesh Terms:

KEYWORDS: Survival Rate

MESH TERMS: epidemiology

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Grant and Affiliation Information for Association between reproductive factors and breast cancer survival in younger women.

AFFILIATION: Department of Epidemiology, University of North Carolina at Chapel Hill, CB #7435, Chapel Hill, NC 27599-7435, USA. trivers@unc.edu

Country: Netherlands

AGENCY: United States NCI

GRANT: T32 CA09330

ACRONYM: CA

MEDLINETA: Breast Cancer Res Treat

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