Association between osteopontin and human abdominal aortic aneurysm.

Association between osteopontin and human abdominal aortic aneurysm. Research Abstract Details 

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Association between osteopontin and human abdominal aortic aneurysm. Abstract Text:

Mazen Shaheen,Neal L Weintraub,

OBJECTIVES: In vitro and animal studies have implicated osteopontin (OPN) in the pathogenesis of aortic aneurysm. The relationship between serum concentration of OPN and variants of the OPN gene with human abdominal aortic aneurysm (AAA) was investigated. METHODS AND RESULTS: OPN genotypes were examined in 4227 subjects in which aortic diameter and clinical risk factors were measured. Serum OPN was measured by ELISA in two cohorts of 665 subjects. The concentration of serum OPN was independently associated with the presence of AAA. Odds ratios (and 95% confidence intervals) for upper compared with lower OPN tertiles in predicting presence of AAA were 2.23 (1.29 to 3.85, P=0.004) for the population cohort and 4.08 (1.67 to 10.00, P=0.002) for the referral cohort after adjusting for other risk factors. In 198 patients with complete follow-up of aortic diameter at 3 years, initial serum OPN predicted AAA growth after adjustment for other risk factors (standardized coefficient 0.24, P=0.001). The concentration of OPN in the aortic wall was greater in patients with small AAAs (30 to 50 mm) than those with aortic occlusive disease alone. There was no association between five single nucleotide polymorphisms or haplotypes of the OPN gene and aortic diameter or AAA expansion. CONCLUSIONS: Serum and tissue concentrations of OPN are associated with human AAA. We found no relationship between variation of the OPN gene and AAA. OPN may be a useful biomarker for AAA presence and growth.

Association between osteopontin and human abdominal aortic aneurysm. Publishing Authors By Initials

M Shaheen,NL Weintraub,

For similar investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: statistics, nonparametric research

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MEDLINE DATE:

Association between osteopontin and human abdominal aortic aneurysm. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Arteriosclerosis, thrombosis, and vascular biology

VOLUME: 27

Page Numbers: 655-60

Journal Abbreviation: Arterioscler. Thromb. Vasc. Bi

ISSN: 1524-4636

DAY: 14

MONTH: 12

YEAR: 2006

Association between osteopontin and human abdominal aortic aneurysm. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9505803

Association between osteopontin and human abdominal aortic aneurysm. Keywords Mesh Terms:

KEYWORDS: Statistics, Nonparametric

MESH TERMS: metabolism

Chemical & Substance for Abstract: Association between osteopontin and human abdominal aortic aneurysm. Information

Substance Name: Osteopontin

Registry Number: 106441-73-0

Grant and Affiliation Information for Association between osteopontin and human abdominal aortic aneurysm.

AFFILIATION: The Vascular Biology Unit, School of Medicine, James Cook University, Townsville, Queensland, 4811 Australia. Jonathan.Golledge@jcu.edu.au

Country: United States

AGENCY: United States NHLBI

GRANT: R01 HL080010-01

ACRONYM: HL

MEDLINETA: Arterioscler Thromb Vasc Biol

REFSOURCE: Arterioscler Thromb Vasc Biol. 2007 Mar;

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