Association between Decreased Kidney Function and Endotoxin Receptor CD14 C-159T Polymorphism among Japanese Health Check-up Examinees.

Association between Decreased Kidney Function and Endotoxin Receptor CD14 C-159T Polymorphism among Japanese Health Check-up Examinees. Research Abstract Details 

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Association between Decreased Kidney Function and Endotoxin Receptor CD14 C-159T Polymorphism among Japanese Health Check-up Examinees. Abstract Text:

Rieko Okada,Koji Suzuki,Yoshinori Ito,Kazuko Nishio,Yoshiko Ishida,Sayo Kawai,Yasuyuki Goto,Mariko Naito,Kenji Wakai,Nobuyuki Hamajima,Rieko Okada,Koji Suzuki,Yoshinori Ito,Kazuko Nishio,Yoshiko Ishida,Sayo Kawai,Yasuyuki Goto,Mariko Naito,Kenji Wakai,Nobuyuki Hamajima,

Background. A recently identified promoter polymorphism of the endotoxin receptor (CD14 C-159T) was shown to be associated with atherosclerotic diseases such as myocardial infarction. This study was conducted to determine whether this polymorphism is associated with decreased kidney function. Methods. A total of 281 male and 522 female health check-up examinees, aged 39-88 years, were genotyped for CD14 C-159T. The glomerular filtration rate (GFR) was estimated by the Modification of Diet in Renal Disease (MDRD) Study equation. Estimated GFR (eGFR) and the proportion of subjects with mildly decreased eGFR (eGFR under 90 mL/min/1.73 m(2)) were compared among the genotypes. Results. Subjects carrying the T allele showed decreased age- and sex-adjusted eGFR compared with those with CC genotype (101+/-22 vs. 105+/-23 mL/min/1.73 m(2); mean+/-SD, p = 0.012). The proportion of subjects with mildly decreased eGFR was higher in T allele carriers (34.2% for TT+CT and 26.3% for CC genotype, p = 0.041), but not statistically significant when adjusted for age and sex (odds ratio [OR] 1.41, 95% CI 0.97-2.05, p = 0.076). In subjects under 65 years, T allele carriers had a significantly increased risk for mildly decreased eGFR (27.1% for TT+CT and 18.0% for CC; age- and sex-adjusted OR 1.82, 95% CI 1.06-3.12, p = 0.030). Conclusion. CD14-159T allele was associated with decreased eGFR compared with CC genotype, and with a higher prevalence of mildly decreased eGFR in younger subjects under 65.

Association between Decreased Kidney Function and Endotoxin Receptor CD14 C-159T Polymorphism among Japanese Health Check-up Examinees. Publishing Authors By Initials

R Okada,K Suzuki,Y Ito,K Nishio,Y Ishida,S Kawai,Y Goto,M Naito,K Wakai,N Hamajima,R Okada,K Suzuki,Y Ito,K Nishio,Y Ishida,S Kawai,Y Goto,M Naito,K Wakai,N Hamajima,

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Association between Decreased Kidney Function and Endotoxin Receptor CD14 C-159T Polymorphism among Japanese Health Check-up Examinees. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Renal failure

VOLUME: 29

Page Numbers: 967-72

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ISSN: 0886-022X

DAY: 10

MONTH: 12

YEAR: 2007

Association between Decreased Kidney Function and Endotoxin Receptor CD14 C-159T Polymorphism among Japanese Health Check-up Examinees. Information

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LANGUAGE: eng

NlmUniqueID: 8701128

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AFFILIATION: Department of Preventive Medicine / Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Country: United States

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MEDLINETA: Ren Fail

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