Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia.

Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Research Abstract Details 

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Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Abstract Text:

F Magri,F Terenzi,T Ricciardi,M Fioravanti,S B Solerte,M Stabile,G Balza,C Gandini,M Villa,E Ferrari,

The circadian organization of adrenal secretion was studied in 23 healthy elderly subjects, 23 elderly demented patients and 10 healthy young subjects, in order to investigate the relationships between the hypothalamic-pituitary-adrenal axis and some cerebral morphometric parameters. The cerebral morphometric analysis was performed in some subjects of the three groups by MRI. A significant increase in cortisol levels during evening and nighttime was found in both groups of the aged subjects. In elderly subjects, particularly if demented, the mean serum dehydroepiandrosterone sulfate (DHEAs) levels throughout the 24-hour cycle were significantly lower than in young controls. A significant reduction of the hippocampal and temporal volume and an enlargement of the lateral ventricles were found in aged subjects, these changes being significantly related to subjects' age. Moreover, the hippocampal volume was positively correlated with the circadian mesor of DHEAs (i.e., the circadian rhythm adjusted mean) and with the cortisol nocturnal increase. Our data may suggest the existence of a link between the selective impairment of cortisol secretion and DHEAs levels, and the progression of hippocampal degeneration.

Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Publishing Authors By Initials

F Magri,F Terenzi,T Ricciardi,M Fioravanti,SB Solerte,M Stabile,G Balza,C Gandini,M Villa,E Ferrari,

For similar behavioral disciplines and activities: psychiatric status rating scales research abstracts see: behavioral disciplines and activities: psychiatric status rating scales research

PUBMED ID PMID:

MEDLINE DATE: 2000 Mar-Apr

Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Dementia and geriatric cognitive disorders

VOLUME: 11

Page Numbers: 90-9

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 24

MONTH: 03

YEAR: 2008

Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9705200

Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Keywords Mesh Terms:

KEYWORDS: Psychiatric Status Rating Scales

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia. Information

Substance Name: Dehydroepiandrosterone Sulfate

Registry Number: 651-48-9

Grant and Affiliation Information for Association between changes in adrenal secretion and cerebral morphometric correlates in normal aging and senile dementia.

AFFILIATION: Department of Internal Medicine and Medical Therapy, Chair of Geriatrics, University of Pavia, Italy. ferrari@ipv36.unipv.it

Country: SWITZERLAND

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MEDLINETA: Dement Geriatr Cogn Disord

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