[Association between angiotensin system gene polymorphism and essential hypertension]

[Association between angiotensin system gene polymorphism and essential hypertension] Research Abstract Details 

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[Association between angiotensin system gene polymorphism and essential hypertension] Abstract Text:

X Li,L Wang,X Han,

OBJECTIVE: To investigate whether angiotensinogen(AGT) M235T, angiotensin II type I receptor(AT(1)R) gene A1166C and angiotensin converting enzyme(ACE) gene I/D polymorphism are implicated in human essential hypertension(HT) in Chinese. METHODS: Polymerase chain reaction(PCR) and PCR combined with restriction enzyme digestion were used to detect AGT gene M235T, AT(1)R gene A1166C variations and ACE gene I/D polymorphism in 161 hypertensive patients and 134 normotensive controls. RESULTS: No statistically significant differences were found in frequencies of the ACE D allele, AGT gene 235T and AT(1)R A1166C between hypertensive patients and normotensive controls, but in hypertensive patients aged <60 years the frequencies of the ACE D allele and AGT gene 235T were significantly higher than those of the normotensive controls (P<0.05). The analysis of combined genotypes of AGT gene and ACE gene showed that the combined genotypes of DD-TT and ID-TT were significantly higher in hypertensive patients than in normotensive controls. Significant relationships between the ACE genotype and serum ACE activity were found in both groups(P<0.05). CONCLUSION: The ACE D allele and AGT 235T polymorphism may be involved in the early occurrence of HT. The combined genotypes of DD-TT and ID-TT may be a dangerous genetic factor for HT in Chinese.

[Association between angiotensin system gene polymorphism and essential hypertension] Publishing Authors By Initials

X Li,L Wang,X Han,

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[Association between angiotensin system gene polymorphism and essential hypertension] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua yi xue yi chuan xue za zhi = Zhonghua yix

VOLUME: 18

Page Numbers: 292-5

Journal Abbreviation: Zhonghua Yi Xue Yi Chuan Xue Z

ISSN: 1003-9406

DAY: 2

MONTH: Aug

YEAR: 2001

[Association between angiotensin system gene polymorphism and essential hypertension] Information

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LANGUAGE: chi

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Grant and Affiliation Information for [Association between angiotensin system gene polymorphism and essential hypertension]

AFFILIATION: Department of Cardiology, Gulou Hospital, School of Medicine of Nanjing University, Nanjing 210008 P.R. China.

Country: China

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MEDLINETA: Zhonghua Yi Xue Yi Chuan Xue Z

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