Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease.

Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Research Abstract Details 

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Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Abstract Text:

Hsiu-Chih Liu,Chen-Jee Hong,Tsung-Yun Liu,Chin-Wen Chi,Shih-Jen Tsai,

In the ongoing search to reveal the pathophysiology of Alzheimer's disease (AD), the cholinergic system is important due to its role in cognitive function and its significance with respect to the results of postmortem pathology and animal model studies. For this investigation, we tested the hypothesis that the allelic variant (C267A) of the cholinergic receptor muscarinic 1 (CHRM1) confers susceptibility to AD or is related to its age of onset, in a sample population of 232 AD patients and 169 normal controls. The distribution of the CHRM1 genotypes (p = 0.919) and alleles (p = 0.327) did not differ significantly comparing AD patients and controls, even after stratification according to apolipoprotein E genotype. The onset age was not significantly different comparing the CHRM1 genotype groups. Our negative findings suggest that it is unlikely that the CHRM1 C267A polymorphism plays a substantial role in conferring susceptibility to AD. We propose that other genetic variations of CHRM1, relating either to AD or to the therapeutic response for AD, may need further investigation.

Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Publishing Authors By Initials

HC Liu,CJ Hong,TY Liu,CW Chi,SJ Tsai,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Dementia and geriatric cognitive disorders

VOLUME: 19

Page Numbers: 42-5

Journal Abbreviation: Dement Geriatr Cogn Disord

ISSN: 1420-8008

DAY: 21

MONTH: 09

YEAR: 2004

Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Information

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LANGUAGE: eng

NlmUniqueID: 9705200

Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

Chemical & Substance for Abstract: Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease. Information

Substance Name: Receptors, Muscarinic

Registry Number: 0

Grant and Affiliation Information for Association analysis for the muscarinic M1 receptor genetic polymorphisms and Alzheimer's disease.

AFFILIATION: Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan, ROC.

Country: Switzerland

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MEDLINETA: Dement Geriatr Cogn Disord

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