Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia.

Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Research Abstract Details 

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Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Abstract Text:

Takahiro Shinkai,Vincenzo De Luca,Rudi Hwang,Daniel J ,Matthew Lanktree,Gwyneth Zai,Sajid Shaikh,Gregory Wong,Tricia Sicard,Natalia Potapova,Joseph Trakalo,Nicole King,Chima Matsumoto,Hiroko Hori,Albert H C Wong,Osamu Ohmori,Fabio Macciardi,Jun Nakamura,James L Kennedy,

A number of linkage studies have previously implicated the region of chromosome 13q34 in schizophrenia. Chumakov and colleagues (2002) identified a gene complex called G72 (now termed D-amino acid oxidase activator: DAOA)/G30 in this region and performed association analyses of the DAOA/G30 as well as the D-amino-acid oxidase (DAAO) gene with schizophrenia. DAAO oxidizes D-serine, a potent activator of the N-methyl-D-aspartate (NMDA) type glutamate receptor in the human brain whereas the DAOA protein is considered an activator of DAAO. The interaction of these two genes has thus been implicated in the NMDA receptor regulation pathway in schizophrenia. To date, several studies have shown a relatively consistent positive association between schizophrenia and DAOA/G30, but not with DAAO. The aim of our study was to further evaluate the contributions of these genes to the susceptibility to schizophrenia using two different sample sets. Our sample consisted of 168 matched case-control pairs as well as a family-based sample (n=113) for transmission disequilibrium test. Significant associations between the DAOA/G30 M-7 and M-18 polymorphisms and schizophrenia were observed in our case-control sample whereas no associations were observed for DAAO markers. We also observed significant or suggestive transmission disequilibrium for DAOA/G30 M-7, M-23, and M-24 to probands with schizophrenia in our family-based sample. Subsequent analysis of haplotypes made up of four DAOA/G30 markers, one marker selected from each of two linkage disequilibrium blocks that were observed in our sample as well as both ends (M-7 and M-25), were also associated with schizophrenia. Our data provide further evidence that the DAOA/G30 locus may play a role in the pathophysiology of schizophrenia. Although no direct link to genetic polymorphism in these genes and NMDA receptor function has been revealed, the present findings support previous reports implicating DAOA/G30 as susceptibility genes for schizophrenia. Further research is warranted to determine the functional variation underlying these findings and to relate this to the pathophysiology of schizophrenia.

Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Publishing Authors By Initials

T Shinkai,V De Luca,R Hwang,DJ ,M Lanktree,G Zai,S Shaikh,G Wong,T Sicard,N Potapova,J Trakalo,N King,C Matsumoto,H Hori,AH Wong,O Ohmori,F Macciardi,J Nakamura,JL Kennedy,

For similar mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research abstracts see: mental disorders: schizophrenia and disorders with psychotic features: schizophrenia research

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Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuromolecular medicine

VOLUME: 9

Page Numbers: 169-77

Journal Abbreviation: Neuromolecular Med.

ISSN: 1535-1084

DAY: 3

MONTH: 12

YEAR: 2007

Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101135365

Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Keywords Mesh Terms:

KEYWORDS: Schizophrenia

MESH TERMS: metabolism

Chemical & Substance for Abstract: Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. Information

Substance Name: D-Amino-Acid Oxidase

Registry Number: EC 1.4.3.3

Grant and Affiliation Information for Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia.

AFFILIATION: Center for Addiction and Mental Health, Department of Psychiatry, University of Toronto, Toronto, Ontario, M5T 1R8, Canada, and Wakato Hospital, Kitakyushu, Japan. shinkai@med.uoeh-u.ac.jp

Country: United States

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MEDLINETA: Neuromolecular Med

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