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Associated autoantibodies in celiac disease.

Associated autoantibodies in celiac disease. Research Abstract Details 

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  • Associated autoantibodies in celiac disease. Abstract Text:

    ron shaoulRon Shaoul,aaron lernerAaron Lerner,ron shaoulRon Shaoul,aaron lernerAaron Lerner,

    Celiac disease (CD) is a life-long inflammatory autoimmune condition of the gastrointestinal tract affecting genetically susceptible individuals. Several autoimmune disorders are more prevalent in patients and their close relatives and that risk is gluten exposure duration related. The most frequent reported CD associated conditions are type 1 diabetes mellitus and autoimmune thyroiditis. Associated autoimmune antibodies are frequent in CD and their first-degree relatives, spanning anti-endocrine, anti-gastrointestinal, anti-nuclear, anti-cytoskeleton and anti-neurological antibodies. More specifically, antibodies against thyroid and the endocrine pancreas, anti-gastric and liver, anti-nuclear constituents, anti-reticulin, actin, smooth muscle, calreticulin, desmin, collagens and bone, anti-brain, ganglioside, neuronal and blood vessel were described in sera of the patients in numerous studies. The common immunogenetic theories for the above associations are: sharing common HLA and non-HLA genes, antigenic mimicry, damage-induced neoantigen exposure, altered intestinal permeability, idiotype network dysregulation and epitope spreading. The CD associated autoantibodies enigma, being an epiphenomenon or pathogenic, remains unresolved and presents a challenging area for future research.

    Associated autoantibodies in celiac disease. Publishing Authors By Initials

    r shaoulR Shaoul,a lernerA Lerner,r shaoulR Shaoul,a lernerA Lerner,

    For similar abstracts research abstracts see: abstracts research

    PUBMED ID PMID:

    MEDLINE DATE:

    Associated autoantibodies in celiac disease. Journal Published:

    PUBLICATION TYPE: Review

    Journal: Autoimmunity reviews

    VOLUME: 6

    Page Numbers: 559-65

    Journal Abbreviation:

    ISSN: 1568-9972

    DAY: 6

    MONTH: 03

    YEAR: 2007

    Associated autoantibodies in celiac disease. Information

    Number of References: 40

    LANGUAGE: eng

    NlmUniqueID: 101128967

    Associated autoantibodies in celiac disease. Keywords Mesh Terms:

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    Grant and Affiliation Information for Associated autoantibodies in celiac disease.

    AFFILIATION: Department of Pediatrics, Bnai Zion Medical Center, Haifa, Israel.

    Country: Netherlands

    Netherlands Research PublicationNetherlands Research Publication

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    MEDLINETA: Autoimmun Rev

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