[Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence]

[Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence] Research Abstract Details 

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[Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence] Abstract Text:

K Morawski,A Gabriel,G Namys?owski,V Pietrawska,A ,P Urbaniec,

The authors estimated PCNA and P53 in subjects with laryngeal cancer in whom local or nodal recurrences were observed. The study included 54 patients from Upper Silesia in age 37-79 years (mean 57 +/- 8.8). The mean value of the PCNA index in subjects with local recurrence (LR) was 24.2% +/- 12.1 while in subjects without LR 22.1% +/- 9.4 (p > 0.05). Additionally, 21 subjects were separated from the investigated group in whom no lymph node metastases were found during laryngectomy. Among these subjects in 16 LR was observed (PCNA index was 30.9% +/- 12.5) while in remaining 5 subjects, in whom LR did not develop, PCNA index was 21.7% +/- 11.2. Analysis of the P53 index in subjects with LR revealed significantly higher values (19.2% +/- 9.1) in comparison to cases without LR (13.2% +/- 6.3). Our study revealed usefulness of the P53 and PCNA as markers which could support the histological diagnostic process describing biology of the cancer cells. The demonstrated increase of PCNA and P53 index in patients with LR might be useful in prediction of LR.

[Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence] Publishing Authors By Initials

K Morawski,A Gabriel,G Namys?owski,V Pietrawska,A ,P Urbaniec,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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[Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Otolaryngologia polska. The Polish otolaryngology

VOLUME: 54 Suppl 31

Page Numbers: 174-7

Journal Abbreviation:

ISSN: 0030-6657

DAY: 28

MONTH: 12

YEAR: 2000

[Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence] Information

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LANGUAGE: pol

NlmUniqueID: 404453

[Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence] Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: metabolism

Chemical & Substance for Abstract: [Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence] Information

Substance Name: Tumor Suppressor Protein p53

Registry Number: 0

Grant and Affiliation Information for [Assessment of usefulness of PCNA and protein p53 in subjects with laryngeal cancer with local recurrence]

AFFILIATION: II Katedra i Klinika Laryngologii Sl. AM w Zabrzu.

Country: POLAND

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MEDLINETA: Otolaryngol Pol

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